Commonwealth Scientific and Industrial Research Organisation

Ppb Technology Pty Ltd

Stephen Charles Trowell

Helen Dacres

John Howard Skerritt

Yonggang Zhu

Amanda Susan Hill

Kim Astrid Garsia

Nam Cao Hoai Le

Nan Wu

Virginia Leitch

Murat Gel

Amalia Berna

Irene Horne

Peter David East

Maggy Sikulu

Gabriele Annerose Lang

Gabriele Annierose Lang

Karine Caron

Benjamin Padovan

Charlotte Williams

Vicki Locke

Stewart Nuttall

Regina Surjadi

Judith Scoble

Mira Maria Dumancic

James McCarthy

Chunyan Liao

Irene Mary Horne

The present invention relates to methods for detecting analytes in a sample. The methods may also be used to determine the amount of analyte in the sample. The present invention also relates to antibody or antibody-like molecules and labelled antigens for use in these methods.

Immunosensor

The present invention relates to sensors and methods for detecting bacterial proteases in a sample. In particular, the present invention relates to sensors and methods for detectingspp. protease activity in a sample. The sensors and methods may be used to detect or predict spoilage of a dairy product. The invention also relates to methods for preparing samples for protease assays.

Protease sensor molecules

The present invention relates to sensors and methods for detecting carbohydrates, such as lactose, in a sample. The sensors and methods may also be used to determine the amount of carbohydrate in the sample.

Carbohydrate sensors

The present invention relates to methods and systems for detecting one or more analytes in a sample and/or for classifying a sample. In particular, the present invention relates to methods and systems which can be used to detect the analytes in real time and which rely on flowing through a microfluidic device one or more types of sensor molecule each comprising a domain that binds one or more analytes, a chemiluminescent donor domain and an acceptor domain, wherein the separation and relative orientation of the chemiluminescent donor domain and the acceptor domain, in the presence and/or the absence of analyte, is within &#xb1;50% of the Forster distance.

Methods and systems for detecting an analyte or classifying a sample

The present invention relates to formulations useful for affecting the behaviour of mosquitoes. More specifically, the present invention relates to formulations for activating mosquitoes such as for attracting mosquitoes. The present invention further provides methods and dispensers incorporating these formulations. The formulation comprises a thio compound as the active, preferably a thioether such as allyl methyl sulphide (AMS), 1-methylthio-propane, 3-methylthio-propanol (MTPL), (E)-1-methylthio-1-propene, (Z)-1-methylthio-1-propene, or derivatives thereof.

Mosquito activating formulations

The present invention relates to methods and systems for detecting one or more analytes in a sample and/or for classifying a sample. In particular, the present invention relates to methods and systems which can be used to detect the analytes in real time and which rely on flowing through a microfluidic device one or more types of sensor molecule each comprising a domain that binds one or more analytes, a chemiluminescent donor domain and an acceptor domain, wherein the separation and relative orientation of the chemiluminescent donor domain and the acceptor domain, in the presence and/or the absence of analyte, is within +50% of the Forster distance.

The present invention relates to a method of identifying a subject with ainfection. The present invention also relates to a method for monitoring a subject with ainfection, for example, following treatment with an anti-malaria compound. Also provided are methods of identifying a compound to treat ainfection.

Methods of detecting plasmodium infection

The present invention relates to methods and polypeptides for detecting a compound in a sample. In particular, the present invention relates to the use of a cell-free composition comprising at least one G protein coupled receptor embedded in a lipid Mayer which when expressed in a cell the N-terminus of the G protein coupled receptor, or subunits thereof, is outside the cell and the C-terminus is inside the cell, and which is capable of binding the compound. Optionally, the composition also comprises at least one accessory molecule that directly or indirectly binds an intracellular loop and/or the C-terminus of the G protein coupled receptor. The G protein coupled receptor, and/or accessory molecule when present, in combination comprise a bioluminescent protein and an acceptor molecule, which enables bioluminescent resonance energy transfer (BRET) to be used to detect the compound binding the receptor.

Measuring G protein coupled receptor activation

Nucleotide and amino acid sequences of luciferase peptides that are encoded by genes within the genome of(Diptera) are disclosed. Specifically provided are functional ATP-dependent luciferases that catalyze luminescence reactions with emission spectra within the blue portion of the spectrum. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and active subsequences of the enzyme peptides, and methods of identifying modulators and substrates of the luciferase peptides. Methods of assays, including multiple reporter assays utilizing at least two ATP-dependent luciferases are provided.

Arachnocampa luciferases

The invention relates to any assay for the identification of nematicidal compounds such as anthelmintics for the control of nematodes. The assay comprises: (i) incubating a nematode sample (i.e. a 'test nematode sample') containing a pre-determined amount of nematodes with an ingestable substrate labelled with a readily detectable label, under conditions suitable for nematode feeding, wherein said incubation is conducted in the presence of said candidate nematicidal compound or follows a pre-incubation of said nematode sample with said candidate nematicidal compound, and (ii) determining whether said candidate nematicidal compound affects nematode feeding by detecting an increase or decrease in ingested substrate as compared to that which has been ingested by a control nematode sample which has been incubated without said candidate nematicidal compound.

Feeding assay for identifying nematicidal compounds

The present invention provides an isolated immunoreactive molecule (IRM) capable of binding to a target molecule from at least one species or sub-species of the insect but not to at least one other species or sub-species of insect and a method of identifying one or more insect species or subspecies and kits therefor. The invention is particularly useful for distinguishing between Lepidopterans such as and and and

Agents and method for identifying insects

An isolated immunoreactive molecule (IRM) capable of binding to a target molecule from at least one species or sub-species of the insect but not to at least one other species or sub-species of insect and a method of identifying one or more insect species or subspecies and kits therefor. The invention is particularly useful for distinguishing between Lepidopterans such as Helicoverpa armigera and H. punctigera.

Growing community of inventors

Oxley, Australia

Stephen Charles Trowell