Other

Abbott Point of Care Inc.

Becton Dickinson and Company Limited

Battelle Memorial Institute

Wardlaw Partners LP

Abbott Laboratories Corporation

Yale University

Idexx Laboratories, Inc.

US Government As Represented by the Secretary of the Army

Coulter Electronics, Inc.

Wardlaw, Stephen

Levine, Robert A.

Wardlaw, Stephen C.

Wardlaw, Stephen Clark

Levine, Robert Aaron

Stephen C Wardlaw

Robert A Levine

Niten V Lalpuria

Darryn W Unfricht

Rodolfo R Rodriguez

Thomas D Haubert

Paul N Fiedler

Min Xie

James Vincent Massey, Iii

David L Rimm

Randy L Jones

Steve Grimes

Vince Contini

Leon W Terstappen

Benjamin Ports

Jeremy R Hill

Thomas J Mercolino

Adrien P Malick

John A Verrant

Igor Nikonorov

Alvydas J Ozinskas

Zhizhou Wang

Robert Holt

Kyle Hukari

David Herzog

Kristen L Manion

R Rodion Rathbone

Graham Davis

John L Haynes

Joshua D Levine

Michael R Loken

Mark Weston Pierson

Charles R Carpenter

Diether J Recktenwald

Craig Stout

Ali Naqui

Stephen J Lovell

Paul Mitsis

Edward Williamson

Michael P Finnerty

Thomas R Weschler

Charles F Galanaugh

Richard R Rathbone

Subhash Dhanesar

Theodore Juraschek

David A Clipper

Brian S Bull

Richard J Torres

Preston Keusch

Stephen C Edberg

William E Neeley

Cord Mueller

Wayne L Brinster

Allan H Hart

Paul N Fielder

Judith Britz

Maurice E Swinnen

Philip C Surh

David Seligson

Matthew W Lesnieskl

Matthew W Lesniesky

John Verrant

A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.

Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion

An apparatus and a method for identifying at least one type of white blood cell (WBC) within a whole blood sample is provided. The method includes: adding at least one colorant to the sample; providing at least one fluorescent excitation light and at least one transmission light; receiving both light fluorescing from and transmitted through the sample and producing signals representative thereof; creating at least one image of the sample using the signals; identifying WBCs within the sample image; quantitatively analyzing at least some of the identified WBCs within the image, including determining one or more quantitative values; and identifying at least one type of WBC from the identified WBCs using the quantitative values.

Method and apparatus for automated whole blood sample analyses from microscopy images

A method for analyzing a biologic fluid sample includes the steps of: a) providing a spatially mapped chamber; b) providing a predetermined repeatable non-uniform spatial distribution of one or more constituents within the sample, which distribution indicates the presence or absence of a statistically significant number of constituents within the sample in each chamber sub-region; c) selecting one or more image techniques for each sub-region based on the presence or absence of the statistically significant number of one or more constituents in that sub-region as indicated by the distribution; d) creating image data representative of the biologic fluid sample in each sub-region, using the one or more image techniques selected for that sub-region; and e) analyzing the sample.

Method for imaging biologic fluid samples using a predetermined distribution

A method and device for analyzing a hematologic sample centrifuged within a capillary tube is provided. The device includes a tube holder, a sample imaging device, a processor, and a sample data display. The sample imaging device is operable to create a digital image of the sample within a region of the tube. The region is defined by substantially all of the radial width and axial length of the sample residing within the internal cavity of the tube in the region where the float resides after centrifugation. The sample imaging device is operable to produce signals representative of the image. The processor is adapted to produce information relating to bands of interest within the image based on the signals from the sample imaging device. The sample data display is adapted to display the results therefrom and/or a digital image of the sample within the region.

Method and apparatus for performing hematologic analysis using an array-imaging system for imaging and analysis of a centrifuged analysis tube

An apparatus for analyzing biologic fluid is provided that includes a first planar member, a second planar member, and at least three separators. At least one of planar members is transparent. The separators are disposed between the members, and separate the members to form a chamber having a height. At least one of the members or separators is sufficiently flexible to permit the chamber height to approximate the mean size of the separators. During use, the biologic fluid to be analyzed is disposed within the chamber.

Disposable chamber for analyzing biologic fluids

A method and apparatus for identifying one or more target constituents (e.g., white blood cells) within a biological sample is provided. The method includes the steps of: a) adding at least one colorant to the sample; b) disposing the sample into a chamber defined by at least one transparent panel; c) creating at least one image of the sample quiescently residing within the chamber; d) identifying target constituents within the sample image; e) quantitatively analyzing at least some of the identified target constituents within the image relative to one or more predetermined quantitatively determinable features; and f) identifying at least one type of target constituent within the identified target constituents using the quantitatively determinable features.

A method for analyzing a blood sample is provided that includes the steps of: providing a blood sample having one or more of each first and second constituents; admixing a colorant with the sample, which colorant is operative to cause the first constituents and second constituents to fluoresce and absorb light; illuminating at least a portion of the sample; e) imaging a portion of the sample; determining a fluorescence value for each the first constituents and second constituents; determining an optical density value for each of the first constituents and second constituents; and identifying the first constituents and the second constituents using the determined fluorescence and optical density values.

Method and apparatus for analyzing individual cells or particulates using fluorescent quenching and/or bleaching

An apparatus for enumerating one or more specific elements within a biologic fluid sample is provided. The apparatus includes a first planar member that is transparent, and a second planar member. The members are separated from one another by a substantially uniform height, and the height is sized relative to the specific elements within the sample such that the specific elements non-uniformly distribute within the sample upon introduction into the chamber.

Apparatus for performing counts within a biologic fluid sample

A method and apparatus for focusing a device for imaging a biologic sample is provided. A method aspect includes the steps of: disposing lenslets within a biologic sample, which lenslets have a height and a refractive index, which refractive index is different from that of the sample, wherein one or both of the imaging device and the sample are relatively locatable so a focal position of the imaging device can be moved along the height of the lenslets; imaging a portion of the sample including lenslets using transmittance at one or more wavelengths; determining an average light transmittance intensity of the sample at the wavelengths; determining an average light transmittance intensity of a region of each lenslet at the wavelengths; and determining the focal position of the imaging device using the average light transmittance intensity of the sample and the average light transmittance intensity of the region of the lenslets.

Method and apparatus for determining a focal position of an imaging device adapted to image a biologic sample

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Lyme, CT, United States of America

Stephen C Wardlaw