Sru Biosystems, Inc.

3m Innovative Properties Company

Minnesota Mining and Manufacturing Company

University of Illinois

X-body, Inc.

Stephen C Schulz

Brian T Cunningham

Bernard O Geaghan

Peter Li

Robert S Moshrefzadeh

Lance Gavin Laing

Craig A Cordeiro

Gangadhar Jogikalmath

Anthony F Chernefsky

Brant Binder

Alex Borsody

Frank J Bottari

Elisa M Cross

Gordon F Taylor

Edward S Hagermoser

Karl P Hauck

John E Van Dine

Richard A Peterson, Jr

Meng Lu

Michael J Kardauskas

L Charles Hardy

Chun Ge

James J Hart

Paul M Hatin

Hermann N Volltrauer

Lech A Michalski

Michael E Badding

A label-free biosensor detection arrangement incorporating an external cavity laser (ECL) includes a tunable lasing element (e.g. an antireflection coated laser diode or semiconductor optical amplifier) and a narrow bandwidth resonant reflectance filter as the wavelength-selective element for the tunable lasing element. A sample is deposited on the surface of the resonant reflectance filter containing a biological material. The wavelength emitted by the external cavity laser is continuously tunable by binding interactions between the biological material and the resonant reflectance filter or adsorption of the biological material present in the sample on resonant reflectance filter. The narrow bandwidth resonance reflectance filter can take the form of photonic crystal (PC), a Bragg stack, or a Brag fiber reflection filter.

External cavity laser biosensor arrangements

A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label-free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used.

Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor

A grating-based biosensor is disclosed where the biosensor is constructed and arranged such that the grating lines of the sensor align with an optical axis of a birefringent substrate, so as to improve resonance peak uniformity. Methods of manufacturing biosensors to provide alignment of the grating lines with the optical axes of a birefringent substrate are also disclosed. One embodiment uses a grating master wafer to form a grating on a continuous web of substrate material. The grating master wafer is rotated relative to the web until the lines of the grating in the master wafer are in substantial alignment with the optical axis of the web. A UV curable material is applied to the wafer and cured in place to form the grating on the surface of the substrate web. With a web of some preferred materials, such as PET film, one need only determine the optical axis orientation once for a given web since the optical axis orientation is essentially constant along the length of the web.

Optimized grating based biosensor and substrate combination

Touch panel systems and methods are disclosed that can distinguish temporally overlapping touch inputs from single touch inputs so that valid touch position coordinates can be determined. Touch panel systems and methods of the present invention can distinguish overlapping touches by comparing signal magnitudes to specified thresholds, by comparing the rates of change of signal magnitudes or measured positions to determined parameters, by locating the proximity a calculated location to icons or other such active areas, and the like. Because touch panel systems and methods of the present invention can discriminate single touches from double touches, they can be used in multiple user applications such as multiplayer games as well as in applications that may be subject to rapidly successive or overlapping touch inputs.

Touch panel system and method for distinguishing multiple touch inputs

A biosensor substrate structure is provided that eliminates the effects of optical interference of light reflected from a substrate/air interface with light reflected by the biosensor's active surface by incorporating a roughened or 'non-specular' surface on the lower surface of the substrate opposite the grating. One can generate a useful non-specular or 'anti-interference' surface in a number of ways in accordance with this disclosure, including (1) by adding a coating of optically diffuse material, such as UV cured acrylate, to the sensor substrate, (2) etching or otherwise roughening the surface of the sensor substrate, or (3) applying a grating structure to the surface.

Biosensor substrate structure for reducing the effects of optical interference

A touch sensing method and a touch sensing device are described for sensing a location of a touch. When the touch sensing device is touched, a first conductive layer disposed on a supporting layer is deflected toward a second conductive layer. The touch location is determined by sensing the change in capacitance at the location of the touch. A change in capacitance at the touch location is sensed by driving one of the conductive layers with an electrical signal referenced to the other conductive layer and measuring the current flow between the conductive layers. The sensed change in capacitance is greater than a change in the external capacitance of the touch sensor.

Touch sensor

Optical component for use in a touch sensor and method of fabrication of same are disclosed. Optical component includes a multilayer optical film at least some layers of which are fabricated on the same manufacturing line and using the same manufacturing method. Each layer of the multilayer optical film is designed primarily to provide a desired associated property.

Multifunctional multilayer optical film

A flexible, capacitive touch sensor, and a method of manufacturing a plurality of such touch sensors, are provided. The capacitive touch sensor comprises a thin, flexible, transparent, insulating substrate. A thin, flexible, transparent layer of resistive material is applied to one side of the substrate, and a thin, flexible, transparent, pressure-sensitive layer of adhesive material is applied to the substrate's other side. A releasable sheet may cover this adhesive layer. A plurality of thin, flexible electrodes, electrical leads and conductive areas are applied to the resistive layer. A thin, flexible, transparent layer of protective material protects the touch sensor's active touch area. Compounds may be added to this protective layer to enhance its conductivity and lubricity. A reel-to-reel process for manufacturing a plurality of such capacitive touch sensors also is described.

Flexible capacitive touch sensor

A sealed insulated glass unit is provided with an electrochromic device for modulating light passing through the unit. The electrochromic device is controlled from outside the unit by a remote control electrically unconnected to the device. Circuitry within the unit may be magnetically controlled from outside. The electrochromic device is powered by a photovoltaic cells. The photovoltaic cells may be positioned so that at least a part of the light incident on the cell passes through the electrochromic device, providing a form of feedback control. A variable resistance placed in parallel with the electrochromic element is used to control the response of the electrochromic element to changes in output of the photovoltaic cell.

Photovoltaic powering and control system for electrochromic windows

Lithium is sputtered from a target with a metallic lithium surface using an alternating sputtering potential with a frequency between about 8 and about 120 kHz, preferably about 10-100 kHz or using a DC sputtering potential and a reverse cleaning potential applied intermittently. The process can be used to apply lithium to electrochromic materials such as coatings on window glass.

Sputtering of lithium

Electrochromic devices are disclosed in which the counterelectrode layer is a gamma phase Li.sub.x V.sub.2 O.sub.5 layer in which x is between about 0.7 and 2.0. In addition, methods of producing electrochromic devices are disclosed including such counterelectrode layers which are heat treated at temperatures of greater than about 260.degree. C. to convert the counterelectrode layer into such a gamma phase Li.sub.x V.sub.2 O.sub.5 layer.

Counterelectrode layer

Lithium is sputtered from a target with a metallic lithium surface using an alternating sputtering potential with a frequency between about 8 and about 120 kHz, preferably about 10-100 kHz. The process can be used to apply lithium to electrochromic materials such as coatings on window glass.

Growing community of inventors

Princeton, NJ, United States of America

Stephen C Schulz