Fisons Ltd.

Stephen C Eyley

Stephen C Coltman

Richard A Raphael

There is disclosed a process for the production of 3-amino-4,6-diacetyl phenol, or a derivative thereof, which comprises reacting a compound of formula III, ##STR1## or a protected derivative thereof, in which R is acetyl or hydrogen, with an excess of acetyl chloride or acetyl bromide and aluminium chloride or aluminium bromide at a temperature of from 30.degree. to 50.degree. C. in an halogenated hydrocarbon solvent.

Production of oxygen and nitrogen substituted benzenes

There is described a process for the production of a 1,4-dihydro-4-oxo-quinoline-2-carboxylic acid, or a salt, ester or amide thereof, which comprises cyclization of a corresponding 2-aminobenzoyl pyruvic acid or an ester thereof, and if desired or necessary converting the resulting product to an appropriate salt, ester or amide thereof, or vice versa.

Growing community of inventors

Loughborough, United Kingdom

Stephen C Eyley