Ethicon, Gmbh

Stephen C Arnold

Rao S Bezwada

Shalaby Wahba Shalaby

Bernard L Williams

Angelo G Scopelianos

Richard D Gooding

A sustained release parenteral composition comprising an admixture of at least one drug to be delivered in a therapeutically effective amount and a bioabsorbable lactone polymer containing one or more lactone monomers that is a liquid at body temperature, provided in an amount effective to sustain or extend the release rate of the drug and a method for administering said composition to an animal.

Liquid absorbable copolymers for parenteral applications

A cosmetic or prosthetic surgical implant comprising an envelope filled with a liquid bioabsorbable polymer and a process for implanting a cosmetic or prosthetic surgical implant involving the filling of an envelope with a liquid bioabsorbable polymer suitable liquid bioabsorbable polymer include lactone copolymers composed of at least two monomers selected from the group consisting of glycolide, L-lactide, D,L-lactide, 1,4-dioxanone, .epsilon.-caprolactone, 1,5-dioxepan-2-one and trimethylene carbonate and poly(orthoesters) of the formula: ##STR1## where R is a linear or branched alkylene group containing 3 to 10 carbon atoms and R' is a linear or branched alkyl group containing 1 to 10 carbon atoms and n is selected to provide a liquid poly(orthester) at body temperature.

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Franklin, NJ, United States of America

Stephen C Arnold