University of South Florida

Rutgers, the State University of New Jersey

Florida International University

Stephen Bryant Liggett

Donghwa Kim

Marcello Angelo Giulianotti

Yu Chen

James William Leahy

David E Kang

Steven An

Eric Lewandowski

Jung A Woo

Disclosed herein are compounds useful for treating obstructive lung diseases. The compounds are TAS2Rs agonists and may further be used to treat disorders and conditions implicated by TAS2R. In some instances the disclosed compounds can be used to treat asthma.

Bronchodilators for treating obstructive lung disease

Disclosed herein are compounds, compositions, and methods for selecting targeting βAR receptors. The compounds, compositions, and methods may be used in the treatment of obstructive lung diseases.

Biased adrenergic agonists

As disclosed herein, β-arrestin1 and β-arrestin2 levels are highly elevated in brains of FTLD-tau patients suggesting that both β-arrestin1 and β-arrestin2 are elevated in the brains of patients with AD and FLTD. The current work also shows that when β-arrestin2 is overexpressed, tau levels become elevated. The data indicate that β-arrestin2 reduces tau clearance by impairing p62-mediated autophagy, a role carried out by the oligomerized form of β-arrestin2. Therefore, disclosed herein are β-arrestin oligomerization inhibitors that can be used to prevent β-arrestin oligomerization and therefore the accumulation of tau in cells, i.e. tauopathy. Also disclosed are methods of treating a tauopathy in a subject that involve administering to the subject a therapeutically effective amount of a β-arrestin oligomerization inhibitor disclosed herein.

Inhibition of beta-arrestin oligomerization in tauopathy

Described herein are let-7f miRNA inhibitors and uses thereof. In some embodiments, the let-7f miRNA inhibitors can be capable of reducing method of reducing &#x3b2;-agonist-mediated &#x3b2;-Adrenergic Receptor (&#x3b2;AR) down regulation in a subject in need thereof.

Compositions and methods to reduce beta-agonist-mediated tachyphylaxis

Growing community of inventors

Treasure Island, FL, United States of America

Stephen Bryant Liggett