Bicycletx Limited

Stephen Blakemore

Peter U Park

Paul John Beswick

Gemma Elizabeth Mudd

Liuhong Chen

Katerine Van Rietschoten

Michael Rigby

Nicholas Keen

Tara Gelb

The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.

Bicyclic peptide ligands specific for Nectin-4

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Littleton, MA, United States of America

Stephen Blakemore