Chirotech Technology Limited

Stephen Benedict David Winter

Ian Campbell Lennon

The present invention pertains to a process for the preparation of an arylphosphine of the formula R,OC&mdash;Ar&mdash;PR,R,wherein Ar is aryl or heteroaryl; R,is an alkoxy or amine group; and R,and R,are each any organic group; and each of the respective groups may optionally be substituted with any non-interfering group; which comprises the reaction of a sulfonyloxy compound of the formula R,OC&mdash;Ar&mdash;OSO,R,wherein R,is alkyl, haloalkyl, perhaloalkyl, aryl, aralkyl or alkaryl, with a phosphine of the formula HPR,R,, in a solvent and in the presence of a palladium catalyst and a base. The arylphosphine can then readily be converted to a chiral phosphine ligand.

Growing community of inventors

Cambridge, United Kingdom

Stephen Benedict David Winter