Genomatica, Inc.

Maxygen, Inc.

Reg Life Sciences, LLC

Ls9, Inc.

Codexis, Inc.

Codexis Mayflower Holdings, LLC

Codexis Mayflower Holding, LLC

Stephen B Del Cardayre

Jeremy S Minshull

Willem P C Stemmer

Matthew B Tobin

Phillip A Patten

Claes Gustafsson

Sergey A Selifonov

Lorraine Joan Giver

Andreas W Schirmer

Zhihao Hu

Louis G Hom

Haibo Wang

Emanuela E Popova

Jay D Keasling

Shane A Brubaker

Jason J Lutes

George M Church

David Arthur Berry

Donald Eugene Trimbur

Myong K Ko

Fernando Valle

Jon Edward Ness

Behnaz Behrouzian

Baolong Zhu

Fernando A Sanchez-Riera

Cindy Chang

Willem Pc Stemmer

Lisa C Friedman

Alma Itzel Ramos-Solis

Bernardo Moura Torres Da Costa

Chris Somerville

Fernando Sanchez-Riera

Qijun Hu

Min Sun Park

Angelica Zabala Bautista

Monica Bhatia

Michael C M Cockrem

Michael Cm Cockrem

Chris Sommerville

The present disclosure relates to chemo-enzymatic processes for the preparation of lactones (including, e.g., macrolactones, γ-lactones, and δ-lactones) and/or macrocyclic ketones, which are compounds of industrial value, for example, for use as fragrance ingredients. The chemo-enzymatic processes combine the in vivo microbial production of fatty acid derivatives and the subsequent ex vivo synthetic transformation of the fatty acid derivatives to provide the lactones and macrocyclic ketones.

Semisynthetic routes to organic compounds

The disclosure relates to engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives including e.g., eight carbon and ten carbon fatty acids and fatty acid derivatives. The disclosure further relates to recombinant host cells comprising the engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives. The disclosure also relates to methods of decreasing toxicity and improving production of medium-chain fatty acids and derivatives.

Thioesterase variants having improved activity for the production of medium-chain fatty acid derivatives

The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.

Methods of producing omega-hydroxylated fatty acid derivatives

The disclosure relates to recombinant microorganisms for the production of fatty amines and derivatives thereof. Further contemplated are cultured recombinant host cells as well as methods of producing fatty amines by employing these host cells.

Recombinant microorganisms for the production of fatty amines

Methods of producing fatty acid esters, such as fatty acid ethyl esters, from genetically engineered microorganisms are described.

Production of fatty acid esters

The present disclosure relates to processes that combine microbial production of organic intermediates and subsequent synthetic transformation to provide compounds of industrial value, including compounds used in fragrances.

Chemo-enzymatic process

The disclosure relates to a recombinant microorganism engineered to express an enzyme which catalyzes the conversion of a primary amine and an acyl thioester to a fatty amide. The disclosure further encompasses a method of producing a fatty amide by culturing the recombinant microorganism in the presence of a carbon source.

Microbial production of alkanolamides and amidoamines and uses thereof

Compositions and methods for production of fatty alcohols using recombinant microorganisms are provided as well as fatty alcohol compositions produced by such methods.

Production of fatty acids and derivatives thereof

Methods of producing olefins, bifunctional molecules, and 7-tetradecene are provided. In some embodiments, the methods comprise subjecting a omega-7-olefinic fatty acid or derivative thereof to metathesis transformation, wherein the omega-7-olefinic fatty acid or derivative thereof was produced in a genetically engineered microorganism.

Metathesis transformations of microbially-produced fatty acids and fatty acid derivatives

Growing community of inventors

Belmont, CA, United States of America

Stephen B Del Cardayre