Warner-Lambert Company

Stephen Alan Fakhoury

Helen Tsenwhei Lee

Karen Elaine Sexton

Haile Tecle

Roy Thomas Winters

Jessica Elizabeth Reed

Kevin Matthew Schlosser

Robert Schaum

This invention provides quinazoline compounds of the formula: 

4-phenylamino-quinazolin-6-yl-amides

This invention provides quinazoline compounds of the formula: wherein: Ris halo; Ris H or halo; Ris a) C-Calkyl, optionally substituted by halo; or b) &#x2014;(CH)-morpholino, &#x2014;(CH)-piperidine, &#x2014;(CH)-piperazine, &#x2014;(CH)-piperazine-N(C-Calkyl), &#x2014;(CH)-pyrrolidine, or &#x2014;(CH)-imidazole; n is 1 to 4; Ris &#x2014;(CH)-Het; Het is morpholine, piperidine, piperazine, piperazine-N(C-Calkyl), imidazole, pyrrolidine, azepane, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH, NH(C-Calkyl) or N(C-Calkyl); m is 1-3; and X is O, S or NH; or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.

This invention provides quinazoline compounds of the formula: wherein: Ris halo; Ris H or halo; Ris a) C-Calkyl, optionally substituted by halo; or b) &#x2014;(CH)-morpholino, &#x2014;(CH)-piperidine, &#x2014;(CH)-piperazine, &#x2014;(CH)&#x2014;-piperazine-N(C-Calkyl), &#x2014;(CH)-pyrrolidine, or &#x2014;(CH)-imidazole; n is 1 to 4; Ris &#x2014;(CH)-Het; Het is morpholine, piperidine, piperazine, piperazine-N(C-Calkyl), imidazole, pyrrolidine, azepane, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH, NH(C-Calkyl) or N (C-Calkyl); m is 1-3; and X is O, S or NH; or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.

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Saline, MI, United States of America

Stephen Alan Fakhoury