Eirgen Pharma Ltd.

Opko Ireland Global Holdings, Limited

Stephen A Strugnell

Charles W Bishop

P Martin Petkovich

Joel Z Melnick

Jay A White

Samir P Tabash

Susan Peers

Susan H Peers

Methods for treating vitamin D insufficiency and secondary hyperparathyroidism in patients having CKD comprising administering repeat doses of 25-hydroxyvitamin D are disclosed. The methods comprise administering 25-hydroxyvitamin D in an amount effective to safely raise the patient's serum 25-hydroxyvitamin D level to greater than 90 ng/ml and/or to control the patient's serum ratio of 25-hydroxyvitamin D to 24,25-dihydroxyvitamin D to less than 20.

Methods of vitamin D treatment

Methods, compositions, and kits for adjunctive therapy using 25-hydroxyvitamin D are disclosed. The 25-hydroxyvitamin D may be administered with an agent that increases the risk of hypocalcemia, such as cinacalcet or a salt thereof, and/or an anticancer agent. The adjunctive therapy is effective to treat and prevent iatrogenic hypocalcemia and/or secondary hyperparathyroidism, as well as delay cancer progression and the time to a post-treatment skeletal related event.

Adjunctive therapy with 25-hydroxyvitamin D and articles therefor

Methods of treating vitamin D insufficiency in chronic kidney disease

Growing community of inventors

Bay Harbor Islands, FL, United States of America

Stephen A Strugnell