Applera Corporation

Perseptive Biosystems Inc.

Stephen A Martin

William W Carson

Michael John Tomany

Stephen C Gabeler

Peter Juhasz

Armin Graber

Yin Liang Hsieh

Dale H Patterson

Anotoli Verentchikov

In various embodiments, the methods for analyzing a sample are provided utilizing a result dependent acquisition strategy. In various embodiments, methods for analyzing a sample are provided wherein the sample is first analyzed by MALDI and MS to produce a first result that is then used to determine a second analysis that is used to analyze the sample again by MALDI and MS/MS or MSto produce a second result.

Method for characterizing biomolecules utilizing a result driven strategy

An interface apparatus for introducing a sample for analysis from a liquid flow into a mass spectrometer as a plurality of charged droplets is disclosed. The interface apparatus includes interface body which defines a spray chamber and an orifice, a spray means defining a liquid-flow inlet channel and an excess-sample-flow exit channel and having an open end disposed inside the spray chamber, and a voltage device for applying a voltage to the sample to form a plurality of charged droplets. The charged droplets pass through the orifice in the interface body and are introduced into a mass spectrometer for analysis. The interface includes a valve for regulating the flow of sample into the sample inlet channel and a device for imposing a pressure gradient on the sample at the open end which induces the sample to flow from the sample inlet channel through the excess sample outlet channel.

Interface between liquid flow and mass spectrometer

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Belmont, MA, United States of America

Stephen A Martin