Medtronic Cryocath LP

Purdue Pharma L.p.

Euro-celtique S.a.

Stephen A Howard

Dan Wittenberger

Jean-Pierre Lalonde

Bruce Reidenberg

Benjamin Oshlack

Curtis Wright

Christopher D Breder

Robert D Colucci

Mark Alfonso

Geraldine Marcenyac

Lino Tavares

Lane Gehrlein

Seth Levy

Ronald Greenbaum

A method and system for creating permanent lesions in an area of target tissue, such as tissue at or proximate a junction between a pulmonary vein and the left atrium. The method may generally include positioning a medical device in contact with a pulmonary vein ostium, ablating the tissue, and recording a plurality of temperature measurements from one or more of three temperature sensors. The device may include an occlusion element in communication with a coolant source, a first sensor located distal of the occlusion element, a second sensor located proximal of the occlusion element, and a third sensor located in the occlusion element. One or more temperature measurements may be compared with each other to assess occlusion of the pulmonary vein, and/or may be compared with a set of reference temperatures to predict a real-time temperature within the target tissue.

Real-time lesion formation assessment

The invention comprises a transdermal dosage form comprising an active agent component comprising an active agent and an adverse agent component comprising an adverse agent, wherein the active agent component defines at least one channel extending substantially there through.

Tamper resistant transdermal dosage form

Disclosed in certain embodiments is a pharmaceutical composition comprising from 10 to 40 mg of oxycodone or a pharmaceutically acceptable salt thereof and 0.65 to 0.90 mg naloxone or a pharmaceutically acceptable salt thereof.

Pharmaceutical combinations of oxycodone and naloxone

The present invention provides a two compartment device (), and method of use, for the disposal of used transdermal dosage forms () and the dispensing of unused transdermal dosage forms (). The first compartment () has a dosage form inlet () and a detector (), and the second compartment () has a dosage form outlet () in communication with the detector (). The detector () permits the dispensing of an unused transdermal dosage () form from the outlet ().

Container and method for dispensing transdermal dosage forms

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Oakdale, MN, United States of America

Stephen A Howard