The Schepens Eye Research Institute, Inc.

Schepens Eye Research Foundation

Stephen A Burns

Robert H Webb

Carl M Penney

Andreas Wilhelm Dreher

Ann E Elsner

An apparatus and a method are disclosed for separating light remitted by a target into a directly scattered light component and at least one multiply scattered light component, detecting the components at least substantially simultaneously, and forming independent sets of image information from each component. The apparatus and the method can be employed in conjunction with techniques such as scanning and tomography to attain precise imaging of biological tissue, including the retina of the eye.

Imaging apparatus and methods for near simultaneous observation of directly scattered light and multiply scattered light

The invention relates to methods and apparatus for determining a characteristic of an optical element. The apparatus includes a spatial light pattern generator adapted to generate a beam of light at a predetermined spatial position, at least one lenslet disposed in an array of lenslets adapted to receive the beam of light from the spatial light pattern generator, and to direct the beam of light to the optical element. The apparatus further includes a detector positioned to receive the beam of light subsequent to the beam of light encountering the optical element. The detector is adapted to detect a received spatial position at which the detector receives the beam of light. The apparatus also includes a processor adapted to compare the predetermined spatial position with the received spatial position to determine the characteristic of the optical element. The invention further relates to methods and apparatus for generating a diffraction limited image. The apparatus includes a spatial light pattern generator adapted to generate a plurality of beams of light at selected spatial positions to compensate for a characteristic of an optical element and an array of lenslets adapted to receive the plurality of beams of light from the spatial light pattern generator and to direct the plurality of beams of light to the optical element. The apparatus also includes an image plane positioned to receive the plurality of beams of light subsequent to the plurality of beams of light encountering the optical element and adapted to form the diffraction limited image.

Methods and apparatus for measurement and correction of optical aberration

A refractometer provides a reference path coaxial with a measurement path and thereby simplifies construction by reducing the number of parts and simplifies maintenance by halving the number of optical axes to be aligned. The refractometer includes a reference projector for projecting a reference pattern on a reference pattern position on a detector during a reference interval, a site-selector for selecting a measurement site on an optical system, and a measurement projector for projecting a measurement pattern through this selected measurement site and onto a measurement pattern position on the detector during a measurement interval. The reference projector, the site selector, and the measurement projector are all aligned along the same optical axis. In the case in which the optical system is a human eye, the designated site in typically a site on the cornea and the detector is the retina of the eye. The refractometer provides an aligner for aligning the reference pattern position with a measurement pattern position. The amount by which these two positions are moved in order to achieve alignment provides a measure of the optimal wavefront corresponding to the measurement site.

Coaxial spatially resolved refractometer

A refractometer provides a reference path coaxial with a measurement path and thereby simplifies construction by reducing the number of parts and simplifies maintenance by halving the number of optical axes to be aligned. The refractometer includes a reference projector for projecting a reference pattern on a reference pattern position on a detector during a reference interval, a site-selector for selecting a measurement site on an optical system, and a measurement projector for projecting a measurement pattern through this selected measurement site and onto a measurement pattern position on the detector during a measurement interval. The reference projector, the site selector, and the measurement projector are all aligned along the same optical axis. In the case in which the optical system is a human eye, the designated site in typically a site on the cornea and the detector is the retina of the eye. The refractometer provides an aligner for alignining the reference pattern position with a measurement pattern position. The amount by which these two positions are moved in order to achive alignment provides a measure of the optimal wavefront corresponding to the measurement site.

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Reading, MA, United States of America

Stephen A Burns