Depuy Synthes Products, Inc.

Depuy Products, Inc.

Stephanie Vass

Weidong Tong

Craig N Ernsberger

Steven N Ginn

Rajendra K Kasinath

Haibo Qu

Lawrence Salvati

An orthopedic implant having a metal surface and a calcium phosphate layer disposed on at least part of the metal surface is described. The calcium phosphate layer has an average crystallite size of less than about 100 nm in at least one direction and dissolves for more than 2 hours in vitro. The calcium phosphate layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.

Orthopedic implant having a crystalline calcium phosphate coating and methods for making the same

An orthopedic implant having a metal surface and a hydroxyapatite layer comprising gallium ions therein disposed on at least part of the metal surface is described. The hydroxyapatite layer has an average crystallite size of less than about 75 nm in at least one direction and dissolves for more than 2 hours in vitro. The hydroxyapatite layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.

Orthopedic implant having a crystalline gallium-containing hydroxyapatite coating and methods for making the same

The present invention relates to articles comprising a cobalt-chromium alloy and bearing a surface oxide layer that has a thickness of 20 to 40 &#x212b;, is enriched in chromium relative to said article, and includes a plurality of indentions that, independently, have a diameter of from about 40 to about 500 nm. Such articles can be suitable for implantation in a mammal.

Nanotextured cobalt-chromium alloy articles having high wettability and method of producing same

The present invention relates to processes involving contacting articles that include titanium or titanium alloy with a solution comprising hydrochloric acid and chloride-containing compound for a time and at a temperature effective to form a plurality of indentions that, independently, have a diameter of from about 200 nm to 10 microns.

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Warsaw, IN, United States of America

Stephanie Vass