Brown University

Scion Pharmaceuticals, Inc.

Stephanie Schorge

Diane Lipscombe

The invention pertains to a human N-type calcium channel isoform, h&#x3b1;, which is involved in central nervous system signaling, and nucleic acids relating thereto. The present invention also includes fragments and biologically functional variants of the human h&#x3b1;channel. Also included are human N-type calcium channel h&#x3b1;subunit inhibitors which inhibit human N-type calcium channel h&#x3b1;subunit activity by inhibiting the expression or function of human N-type calcium channel h&#x3b1;subunit. The invention further relates to methods of using such nucleic acids, polypeptides, and inhibitors in the treatment and/or diagnosis of disease, such as in methods for treating stroke, pain, e.g., neuropathic pain, and traumatic brain injury.

Human N-type calcium channel isoform and uses thereof

The invention pertains to a human N-type calcium channel isoform, h&agr; , which is involved in central nervous system signaling, and nucleic acids relating thereto. The present invention also includes fragments and biologically functional variants of the human h&agr; channel. Also included are human N-type calcium channel h&agr; subunit inhibitors which inhibit human N-type calcium channel h&agr; subunit activity by inhibiting the expression or function of human N-type calcium channel h&agr; subunit. The invention further relates to methods of using such nucleic acids, polypeptides, and inhibitors in the treatment and/or diagnosis of disease, such as in methods for treating stroke, pain, e.g., neuropathic pain, and traumatic brain injury.

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Charvil, United Kingdom

Stephanie Schorge