Industrial Microbes, Inc.

Lanzatech, Inc.

Stephanie Rhianon Jones

Baolong Zhu

Elizabeth Jane Clarke

Derek Lorin Greenfield

Noah Charles Helman

Michael Koepke

Sean Dennis Simpson

James MacAllister Clomburg

Timothy James Politano

Juniper Dee Gramling

Jaeyoung Jung

Ryan Christopher Tappel

Nicholas Alexander Fackler

Methods and compositions for the oxidation of short alkanes by engineered microorganisms expressing enzymes are described, along with methods of use.

Heterologous expression of short-chain monooxygenases in microorganisms

Microorganisms are genetically engineered to continuously co-produce amino acids, proteins, microbial biomass, chemicals, or any combination thereof by microbial fermentation, particularly by microbial fermentation of a gaseous substrate. The microorganisms are C1-fixing. The production of ethylene, microbial biomass, and heterologous tandem repeat proteins can be improved. This can be effected by improved promoters or nutrient limiting means.

Microorganisms and methods for the continuous co-production of tandem repeat proteins and chemical products from C1-substrates

Improved soluble methane monooxygenases and soluble methane monooxygenase systems are provided.

Methane monooxygenase enzymes

Microorganisms are genetically engineered to continuously co-produce amino acids, high-value, specialized proteins, microbial biomass, chemicals, or any combination thereof by microbial fermentation, particularly by microbial fermentation of a gaseous substrate. The microorganisms are C1-fixing. The production of ethylene, microbial biomass, and heterologous high-value, specialized proteins can be improved. This can be improved by varying promoters or nutrient limiting means.

Microorganisms and methods for the continuous co-production of high-value, specialized proteins and chemical products from C1-substrates

The disclosure provides genetically engineered C1-fixing microorganisms capable of producing nanobodies. Additionally, the disclosure provides engineered microorganisms comprising one or more disrupted genes to strategically divert carbon flux away from nonessential or undesirable products towards products and/or co-products of interest. The disclosure enables co-production of useful chemicals from gaseous substrates.

Recombinant microorganisms and uses therefor

Method for producing a chemical with synthetic microorganism encoding a monooxygenase

Methods and compositions for the oxidation of short alkanes by engineered microorganisms expressing recombinant enzymes is described, along with methods of use.

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Berkeley, CA, United States of America

Stephanie Rhianon Jones