Basf Se Corporation

Stephanie Portmann

Barbara Wagner

Bernd Herzog

Gabriele Baisch

Reinhold Öhrlein

Kai Eichin

Described is the use of benzotropolone and their derivatives, especially the compounds of formula (1); wherein R, R, R, Rand Rindependently of one another are hydrogen; OH; C-Calkyl, C-Cal-kenyl, C-Calkoxy, C-Ccycloalkyl or CChydroxyalkyl, which may be substituted by one or more E and/or interrupted by one or more D; C-Caryl, which may be substituted by one or more G; C-Cheteroaryl, which may be substituted by one or more G, C-Calkenyl, C-Calkynyl, C-Caralkyl, CN, or &#x2014;CO&#x2014;R; C-Cmono- or dialkylamino; COR; COOR; CONRR; CN; SOR; OCOOR; OCOR; NHCOOR; NRCOR; NH; *&#x2014;(CO)&#x2014;NH&#x2014;(CH)&#x2014;(PO)&#x2014;(OR); &#x2014;(CO)&#x2014;O&#x2014;(CH)&#x2014;(PO)&#x2014;(OR); sulphate; sulphonate; phosphate; phosphonate; &#x2014;(CH)&#x2014;[O&#x2014;(SO)]&#x2014;OR; &#x2014;O&#x2014;(CH)(CO)&#x2014;R; &#x2014;(O)&#x2014;(CH)&#x2014;(PO)&#x2014;(OR); &#x2014;(O)&#x2014;(CH)&#x2014;SO&#x2014;OR; halogen; organosilanyl; organo-siloxanyl; or a sugar residue linked directly in an &#x3b1;- or &#x3b2;-mode via the anomeric oxygen to the benzotropolone system or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH)&#x2014;(X)-benzotropolone system, wherein n=1-10 and X&#x2550;&#x2014;O&#x2014;; &#x2014;(CO)&#x2014;; &#x2014;O&#x2014;CO&#x2014;; &#x2014;COO&#x2014;, &#x2014;NH&#x2014;; &#x2014;S&#x2014;; &#x2014;SO&#x2014;); R, Rand Rindependently of one another are hydrogen; CCalkyl or C-C-cycloalkyl, which may be substituted by one or more E and/or interrupted by one or more D; C-Caryl, which may be substituted by one or more G; C-Cheteroaryl, which may be substituted by one or more G, C-Calkenyl, C-Calkynyl, C-Caralkyl, or COOR; COR; CONRR; SOR; SOR; PO(R); PO(R); organosilanyl; organosiloxanyl; or a sugar residue linked directly in an &#x3b1;- or &#x3b2;-mode via the anomeric oxygen to the benzotropolone system or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH)&#x2014;(X)&#x2014;*, wherein n=1-10 and X&#x2550;&#x2014;C(&#x2550;O)&#x2014;; &#x2014;O&#x2014;CO&#x2014;*); Rand Rindependently from each other are hydrogen; CCalkyl or C-C-cycloalkyl which may be substituted by one or more E and/or interrupted by one or more D; C-Caryl, which may be substituted by one or more G; C-Cheteroaryl, which may be substituted by one or more G; organosilanyl; organosiloxanyl; or a sugar residue linked directly in an &#x3b1;- or &#x3b2;-mode via the anomeric oxygen or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH)&#x2014;*, wherein n=1-10); or Rand Rtogether form a five or six membered ring, Ris hydrogen; or C-Calkyl; n, n, nand nindependently from each other are a number from 1 to 5; n, nand nindependently from each other are a 0; or 1; D is &#x2014;CO&#x2014;; &#x2014;COO&#x2014;; &#x2014;S&#x2014;; &#x2014;SO&#x2014;; &#x2014;SO2-; &#x2014;O&#x2014;; &#x2014;NR&#x2014;; &#x2014;SRR&#x2014;; &#x2014;POR&#x2014;; &#x2014;CR&#x2550;CR&#x2014;; or &#x2014;C&#x2261;C&#x2014;; and E is &#x2014;OR; &#x2014;SR; &#x2014;NRR; &#x2014;NRCOR; &#x2014;COR; &#x2014;COOR; &#x2014;CONRR; &#x2014;CN; halogen; Or SOR; SOR; PO(R); PO(R); organosilanyl; organosiloxanyl; or a sugar residue linked directly in an &#x3b1;- or &#x3b2;-mode via the anomeric oxygen or via a linear or branched alkylene, alkenylene, alkadiene or alkatriene spacer (sugar-(CH)n-(X)&#x2014;*, wherein n=1-10 and X1=&#x2014;O&#x2014;; &#x2014;C(&#x2550;O)&#x2014;; &#x2014;O&#x2014;CO&#x2014;; &#x2014;COO&#x2014;; &#x2014;NH&#x2014;; &#x2014;S&#x2014;; &#x2014;SO&#x2014;); G is E; C-Calkyl, which is optionally interrupted by D; C-Cperfluoroalkyl; C-Calkoxy, which is optionally substituted by E and/or interrupted by D; wherein R, R, Rand Rindependently of each other are hydrogen; C-Caryl which is optionally substituted by OH, C-Calkyl or C-Calkoxy; C-Calkyl, which is optionally interrupted by &#x2014;O&#x2014;; or Ri4 and Ri5 together form a five or six membered ring, Ri6 is hydrogen; C6-Ci8aryl which is optionally substituted by OH, C-Calkyl or d-Calkoxy; C-Calkyl which is optionally interrupted by &#x2014;O&#x2014;; Ris H; C-Caryl which is optionally substituted by OH, C-Calkyl or C-Calkoxy; or d-Calkyl which is optionally interrupted by &#x2014;O&#x2014;; Ris hydrogen; C-Caryl, which is optionally substituted by OH, C-Calkyl or d-Calkoxy; C-Calkyl, which is optionally interrupted by &#x2014;O&#x2014;; Rand Rindependently of each other are hydrogen; C-Calkyl; C-Caryl which is optionally substituted by C-Calkyl; and Ris C-Calkyl; or C-Caryl, which is substituted by C-Calkyl; * means, that this radical is directed to the benzotropolone moiety; for the protection of human and animal hair and skin against UV radiation. 

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Basel, Switzerland

Stephanie Portmann