Advanced Bionics Ag

The Secant Group, LLC

Stephanie M Reed

James George Elcoate Smith

Sung Jin Lee

Jeryle L Walter

Uli Gommel

Peter D Gabriele

Jeremy J Harris

Charles Brendan Nicholson

Carissa Smoot

Jared Ely

Todd Crumbling

Dennis Shull

John D'Ottavio

Ryan R Smalley

Alexander M Stahl

Amanda K Weber

Manasi Chawathe Baker

A delivery system is described that includes a controlled release device that includes a crosslinked poly(glycerol sebacate) (PGS) or other glycerol ester and a controlled release compound, the controlled release device being provided in a contracted state and being expandable to a three-dimensional expanded state in a target location. The delivery systems provides an expandible, flexible biodegradable elastomer loaded with an active ingredient to allow for extended release for different dosage forms for either human or animal health products in vivo, delivered through the gastrointestinal tract.

Shape-guided controlled release and retention with structures including crosslinked poly(glycerol sebacate)

A cochlear implant including a cochlear lead, an antenna, a stimulation processor, and a magnet apparatus, associated with the antenna, including a case defining a central axis, a magnet frame within the case and rotatable about the central axis of the case, and a plurality of elongate diametrically magnetized magnets that are located in the magnet frame, the magnets defining a longitudinal axis and a N-S direction and being freely rotatable about the longitudinal axis relative to the magnet frame.

Cochlear implants having MRI-compatible magnet apparatus and associated methods

A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.

Tunable, controlled-release, urethane-containing elastomers and processes of forming the same

MRI-compatible magnet apparatus

A particle alignment method in accordance with at least one of the present inventions includes the step of positioning a cochlear implant, which is implanted within a patient's head and which includes a magnet apparatus with a central axis and magnetic material particles, at a location outside of the scanning area of an MRI system, adjacent to the MRI system, and within the MRI magnetic field in such a manner that the central axis of the magnet apparatus is at least substantially parallel to the MRI magnetic field.

Methods and apparatus for use with cochlear implants having magnet apparatus with magnetic material particles

A method of forming a skin care product includes combining at least one additive including at least one active ingredient with at least one glycerol-sebacate component having repeating units of (glycerol sebacate), water, a co-solvent, and at least one of an emulsifier, a surfactant, and a bodying agent to form the skin care product. A dermocosmetic composition includes at least one additive including at least one active ingredient and at least one glycerol-sebacate component having repeating units of (glycerol sebacate). A method of skin care includes applying a dermocosmetic composition to a skin surface.

Dermocosmetic compositions including glycerol-sebacate

A cochlear implant including a cochlear lead, an antenna, a stimulation processor, and a magnet apparatus, associated with the antenna, including a case defining a central axis, a magnet frame within the case and rotatable about the central axis of the case, and a plurality of diametrically magnetized magnets that are located in the magnet frame, the magnets defining a longitudinal axis and a N-S direction and being rotatable about the longitudinal axis relative to the magnet frame and biased by the magnet frame to a predetermined N-S rotational orientation.

A magnet apparatus including a case defining a central axis, a magnet frame within the case and rotatable about the central axis of the case, and a plurality of elongate diametrically magnetized magnets that are located in the magnet frame, the magnets defining a longitudinal axis and a N-S direction and being freely rotatable about the longitudinal axis relative to the magnet frame.

Growing community of inventors

Los Angeles, CA, United States of America

Stephanie M Reed