Merck Sharp + Dohme Corp.

Stephanie M Chichetti

Alexey A Rivkin

Sean P Ahearn

Benito Munoz

Joey Lee Methot

Christian Fischer

Matthew Christopher

Rachel Nicola MacCoss

Chaomin Li

Adam J Schell

William Colby Brown

Sam Kattar

Andrew Rosenau

The invention encompasses pyrimidine derivatives as gamma secretase modulators, useful for treating diseases associated with the deposition of beta-amyloid peptide in the brain, such as Alzheimer's disease, or of preventing or delaying the onset of dementia associated with such diseases. Pharmaceutical compositions and methods of use are included.

Pyrimidine derivatives for treatment of alzheimer's disease

According to the invention there is provided a compound of formula I or a pharmaceutically acceptable salt or hydrate thereof; wherein the variables are as defined herein. The compounds selectively attenuate the production of A&#x3b2;42 and hence are useful in treatment of Alzheimer's disease and related conditions. 

Triazole derivatives for treatment of Alzheimer's disease

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Brookline, MA, United States of America

Stephanie M Chichetti