Battelle Memorial Institute

Avent, Inc.

Stephanie Kute

Andrew Sweeney

Chad Edward Bouton

Amy M Heintz

Steven Risser

Thomas D Haubert

Gaurav Sharma

Nicholas Annetta

George Brand

Matthew Edward Mowrer

Raymond Richard Zaborski

Alexander Morrow

Jeffrey A Friend

John Gavin MacDonald

Ramanathan S Lalgudi

Brian Joseph Cuevas

Alison Salyer Bagwell

Jeffrey L Ellis

Anthony David Duong

John Bartholomew

Rachel Thurston

Cherry Gupta

Danielle J Huk

Kenneth R Sims, Jr

Jacob Lilly

Mike Koeris

David William Koenig

Kelly Dean Branham

Phillip A Schorr

C Alexander Morrow

Karien J Rodriguez

Jeffrey Friend

Reade Harpham

David James McNamara

Steven M Risser

Phillip Andrew Schorr

Andrew V Sweeney

The invention relates to polymer nanoparticle and DNA nanostructure delivery compositions for non-viral delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticle delivery compositions, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, and DNA nanostructure delivery compositions, such as DNA origami compositions, for the delivery of more than one payload, or for the delivery of a nucleic acid construct payload of 3 kB or more, and methods therefor.

Polymer nanoparticle and DNA nanostructure compositions and methods for non-viral delivery

The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.

Neural sleeve for neuromuscular stimulation, sensing and recording

A wound dressing system that includes a conformal cover and an infusion pump is provided. The cover includes a fluid port and an oxygen catalyst. The infusion pump is configured to deliver a bioactive liquid to the cover via the fluid port. The liquid includes an oxygen precursor. Upon combination, the oxygen catalyst and precursor react to form oxygen. A method of applying a wound dressing system including a bioactive powder, a bioactive liquid, and a conformal cover to a wound site is also provided. The method includes applying the powder to the wound site; securing the cover around the wound site, where the cover includes an oxygen catalyst and a fluid port; and delivering the bioactive liquid to at least an inner layer of the cover via the fluid port, where the bioactive liquid includes an oxygen precursor.

Traumatic wound dressing system with conformal cover

A wound dressing system comprising a wrap and a frangible ampoule is provided. The wrap is configured to contact/surround a wound site and includes an oxygen catalyst. The ampoule includes an oxygen precursor. The catalyst and precursor are configured to form oxygen when combined. A wound dressing system including a container is also provided that includes a powder, wrap, and frangible ampoule. The powder is disposed within the container, which is configured to allow the powder to be dispersed onto a wound site when activated. The wrap, which may include an oxygen catalyst, is also disposed in the container and is configured to contact/surround the wound site. The ampoule, also disposed in the container, includes a liquid containing an oxygen precursor. The liquid is configured to contact the wrap when the container is activated. Further, the catalyst and precursor are configured to form oxygen when combined.

Traumatic wound dressing system with wrap

Growing community of inventors

Columbus, OH, United States of America

Stephanie Kute