Cohera Medical, Inc.

Stephanie Kladakis

Dottie M Clower

Despina Dobbins

Dottie Clower

A tissue sealant that includes the reaction product of (a) a polyol; (b) a polyisocyanate; and (c) an alkoxy silane having the formula: (RRR)&#x2014;Si&#x2014;CH&#x2014;Z where (i) Z is an &#x2014;OH, &#x2014;SH, &#x2014;NCO, or &#x2014;NHRgroup, where Ris hydrogen, an alkyl group, or an aryl group; and (ii) each R, R, and R, independently, is H, an alkoxy group, an alkyl group, a heteroalkyl group other than an alkoxy group, an aryl group, or a heteroaryl group, with the proviso that at least two of R, R, and Rare alkoxy groups, the relative amounts of the polyol, polyisocyanate, and alkoxy silane being selected such that the reaction product comprises free isocyanate groups. The tissue sealant is moisture-curable and biodegradable in a physiological environment.

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Pittsburgh, PA, United States of America

Stephanie Kladakis