Gruenenthal Gmbh

Grunenthal Gmbh

Stephanie Harlfinger

Babette-Yvonne Koegel

Klaus Linz

Paul Ratcliffe

Bert Nolte

Fritz Theil

Anita Wegert

Birgit Braun

Olga Groeger

Stefan Schunk

Derek John Saunders

Sven Kuehnert

Rene Michael Koenigs

Sonja Steufmehl

The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the &#x3bc; opioid receptor and/or the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.

Substituted azaspiro(4.5)decane derivatives

The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the &#x3bc; opioid receptor and the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.

Spirocyclic cyclohexane compounds corresponding to formula I in which Rand Rform a pyrrolidine ring or an azetidine ring and which exhibit increased metabolic stability, a process for producing such spirocyclic cyclohexane compounds, pharmaceutical compositions containing such spirocyclic cyclohexane compounds, and the use of such spirocyclic cyclohexane compounds to treat or inhibit pain and/or other disorders.

Spirocyclic cyclohexane compounds

Growing community of inventors

Basel, Germany

Stephanie Harlfinger