Laboratoires Expanscience

Laboratories Expanscience

Stephanie Bredif

Caroline Baudouin

Philippe Msika

Sophie Leclere-Bienfait

Sebastien Garnier

Sebastien Debrock

Gaelle Bellemere

Gaetan Boyer

Marisa Meloni

The present invention relates to models of reconstructed sensitive skin reproducing the features of sensitive skin, as well as to processes for obtaining such models. The present invention further relates to in vitro processes for testing formulations or active ingredients for the prevention or treatment of sensitive skin.

Models of reconstructed sensitive skin

The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is dry. Such markers are particularly advantageous in that they allow the skin's response to dehydration to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of dehydration on children's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.

Method for evaluating the effects of dehydration on children's skin

The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is affected by atopic dermatitis. Such markers are particularly advantageous in that they allow the skin's response to atopic dermatitis to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of atopic dermatitis on a child's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.

Juvenile atopic dermatitis models

The invention relates to a composition comprising an extract of passionflower seeds, and preferentiallyseeds. The composition is advantageously cosmetic, pharmaceutical, dermatological or nutraceutical. The subject matter of the invention is also a process for extracting an extract of passionflower seeds and preferentiallyseeds, and also the extract which can be obtained by means of said process. The invention also relates to such a composition or such an extract for use in the prevention or treatment of disorders or pathological conditions of the skin, of the mucous membranes or of the skin appendages, for use in the prevention or treatment of vascular disorders, for use for combating oxidative stress, or else for use in the prevention or treatment of adipose tissue modifications. Finally, the invention relates to a cosmetic care process for the skin, the skin appendages or the mucous membranes, with a view to improving, the condition thereof or the appearance thereof, consisting in administering such a composition or such an extract.

Extract of passionflower seeds and cosmetic, pharmaceutical, dermatological and nutraceutical compositions comprising same

A method to treat skin or mucosa cells or disorders related to dermal tissue by topically administering to a person in a need thereof a lipid extract fromseeds selected fromseeds,seeds, and a combination thereof, wherein said lipid extract is oil ofseeds concentrated in its unsaponifiable fraction containing 3 to 100 weight % of unsaponifiables relative to the total weight of the extract.

Methods of treatment using a lipid extract ofseeds concentrated in its unsaponifiable fraction

A skin model comprises keratinocytes capable of overexpressing filaggrin. A method for evaluating the in vitro activity of a formulation or of at least one active agent on the healing of nipple skin and/or on the reduction of nipple skin inflammation, by bringing said active agent or said formulation into contact with a skin model comprising keratinocytes overexpressing filaggrin and also comprising a lesion, and measuring the level of production of at least one biological marker chosen from lactate dehydrogenase (LDH), TNF&#x3b1;, filaggrin, TGF&#x3b2;1 and &#x3b2;1 integrin.

Reconstituted nipple skin model

The invention relates to a method for evaluating the effectiveness of an active ingredient selected from C7 avocado sugars, also called avocado perseose, for preventing or treating a deficiency of the skin barrier, said method comprising the determination of the level of expression and/or activation of at least one biological marker, where said biological marker is selected from epidermal maturation markers, lipid barrier markers, hydric regulation markers andregulation markers.

Use of biomarkers for evaluating the effectiveness of active ingredients

The invention relates to in vitro methods for testing formulations or active ingredients for preventing the harmful effects of UV on children's skin, in particular children aged three or less. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the harmful effects of UV on the skin of children aged three or less, using a skin model specifically capable of reproducing the characteristics of the skin of children of this age.

Growing community of inventors

Croisilles, France

Stephanie Bredif