Bristol-myers Squibb Compnay

Bristol Meyers Squibb Company

Stephanie Barbosa

Zhen-Wei Cai

Rajeev S Bhide

Ligang Qian

Louis John Lombardo

Jeffrey A Robl

Junying Fan

Mark E Salvati

John T Hunt

Donna Wei

Gerard Crispino

Luca Parlanti

Francis S Gibson

Zhong Chen

The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Inhibitors of kinases

The present invention is directed to intermediates that are useful for preparing pyrrolotriazines, and processes for preparing such intermediates.

Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors

Pyrrolotriazine kinase inhibitors

The present invention relates to a process for preparing certain pyrrolotriazine compounds of the formulaand pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Process for preparing certain pyrrolotriazine compounds

Disclosed are pyrrolopyridazine compounds of the formula,

Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders

The present invention provides compounds of formula I,and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Pyrrolo[2,1-f][1,2,4]triazine inhibitors of kinases

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Lambertville, NJ, United States of America

Stephanie Barbosa