Exelixis, Inc.

Stephanie A Robertson

Lori Friedman

Marcia Belvin

Danxi Li

Gregory D Plowman

Jeffrey Scott Larson

Darren Platt

Andrew Roy Buchman

Roel P Funke

Kevin Patrick Keegan

Casey Kopczynski

Wen Shi

Mario N Lioubin

Madelyn Robin Demsky

Jeffery S Larson

Changyou Chen

Jocelyn Chan

Lynn Marie Young

Michael Martin Ollman

Human HADH genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of HADH are provided.

HADHs as modifiers of the p21 pathway and methods of use

Rhomboid Related Proteins (RRPs), involved in the EGFR signaling pathway, are provided. Transgenic, nonhuman mammals containing a transgene encoding an RRP polypeptide or a gene effecting the expression of an RRP polypeptide, along with methods of modulating the interaction of RRP proteins with their pathway members, and methods of screening for agents that modulate the interaction of an RRP polypeptide with an RRP binding target, such as RRP-specific antibodies and small molecules identified in high throughput screens, are also provided. Modulating agents identified using the methods of the invention can be used to specifically inhibit growth of tumor cells that overexpress an RRP protein.

Human RRP sequences and methods of use

A family of p53 tumor suppressor nucleic acid and protein isolated from several insect species is described. The p53 nucleic acid and protein can be used to genetically modify metazoan invertebrate organisms, such as insects and worms, or cultured cells, resulting in p53 expression or mis-expression. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds that are potential pesticidal agents or therapeutics that interact with p53 protein. They can also be used in methods for studying p53 activity and identifying other genes that modulate the function of, or interact with, the p53 gene. Nucleic acid and protein sequences for Drosophila p33 and Rb tumor suppressors are also described.

Insect p53 tumor suppressor genes and proteins

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San Francisco, CA, United States of America

Stephanie A Robertson