Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Université Nice Sophia Antipolis

Université Cote D'azur

Inserm

Stephane Rocchi

Rachid Benhida

Robert Ballotti

Cyril Ronco

Magali Plaisant

Antoine Millet

Michael Cerezo

Maria Duca

Jean-Patrick Joly

Emile Jaune

Oleksandr Grytsai

Nedra Tekaya

The present disclosure relates to biguanide derivatives of formula (I) and their rearrangement products. The present disclosure also relates to the use of these compounds in a method for treating cancer, in particular melanoma. 

Biguanide derivatives and their rearrangement products for use in the treatment of cancer

The present invention relates to compound of general formula (I) Ris selected from H, aryl and alkyl, Ris selected from H, alkyl, aryl and CO&#x2014;R; Ris selected from H, halogen, alkyl, alkenyl, alkynyl, aryl, NHR, NRR, ORand SR; Ris selected from (C-C) alkyl, (C-C) alkenyl, (C-C) alkynyl and (C-C) aryl, Rrepresents H, R, aryl, OH, OR, O-aryl, SH, SR, S-aryl, CN, NO, CF, COOR, SONRR, CONRR, NH, NHR, NH-aryl, NRR, NHCORor aminoacyl; Ris alkyl optionally substituted with halogen, OH, SH, NH, O-alkyl, S-alkyl, NH-alkyl or NH-di(alkyl); Rand Ridentical or different are H or alkyl optionally substituted with halogen, OH, SH, NH, O-alkyl, S-alkyl, NH-alkyl or NH-di (alkyl), their pharmaceutically acceptable salts and/or isomers, tautomers, solvates or isotopic variations thereof. The compounds are useful for the treatment of cancers. 

Substituted hydrophobic benzene sulfonamide thiazole compounds for use in treating cancer

The present invention relates to compound of general formula (1) wherein Rrepresents C-Caryl comprising one or two fused rings, wherein from 2 to 5 carbon atoms may be replaced with a heteroatom selected from O, S and NR, and eventually substituted with from 5 to 11 substituents selected from R, halo, CN, NO, CF, OCF, COOR, OCOR, SONRR, CONRR, NRR, NRCOR, (CH)&#x2014;NRR, (CH)&#x2014;ORand (CH)SR, as well as, if appropriate, their pharmaceutically acceptable salts and/or isomers, tautomers, solvates or isotopic variations thereof. The compounds are useful for the treatment of cancers. 

Benzene sulfonamide thiazole compounds

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Nice, France

Stephane Rocchi