Emd Millipore Corporation

Merck Patent Gmbh

Millipore Corporation

Stephane Olivier

Didier Metz

Gerard Muller

Mathieu Arrault

Jerome Geyer

Gaetan Bour

Christian Schann

Luc Felden

Christian Clauss

Pierre Guedon

Fabrice Comini

Alan J Weiss

Florian Allard

A mixing device () for cyclically imparting a force on an external surface (A) of a bag (B) for agitating a content (C) of the bag (B), the mixing device () comprising a lever () supported so as to be able to pivot about a pivot (), a weight () provided on a first side of the lever (), a driver () arranged to cooperate with the lever (), a motor () for moving the driver () to lift the first side of the lever () with the weight () against gravity and to drop the first side against the external surface (A) of the bag (B), and a holder () for supporting the mixing device () such that the first side of the lever () can contact the external surface (A) of the bag (B) in the drop motion.

Mixing device

The invention relates to the filtering of liquid samples, preferably in a laboratory environment, for example for collecting micro organisms from the liquid sample for subsequent testing. The invention provides a method for filtering a liquid sample which comprises providing a blank of a deformable sheet material and a filtration medium, deforming the blank to form a funnel extending above and about the filtration medium, introducing the liquid sample to be filtered into the so formed funnel, and filtering the liquid sample from the funnel through the filtration medium, for example to a downstream receptacle. The method is accordingly based on the concept that the funnel is not or at least not completely preformed but provided in a form of a blank of a deformable material sheet which is deformed so as to form the funnel at the point and time of use during filtration.

Method and apparatus for filtering a liquid sample

The invention relates to a tubing device for sterile media including a container for storing sterile media, a discharge port for discharging liquid sterile media, an inlet port for introducing fluid into the tubing device and a multiple-way-connector. The multiple-way-connector is connected to the container, the discharge port, the inlet port, and an apparatus for preparing, mixing and discharging a sterile medium for use with a tubing device, including a water inlet port for introducing water, a water outlet port configured to be connected to the inlet port of the tubing device, a fluid pump for conveying the fluid, the fluid pump is connected to the fluid inlet port and the water outlet port and a container support for supporting the container of the tubing device.

System and apparatus for discharging sterile media

A sample preparation device () comprising a first chamber () containing a membrane support () on which a membrane () is placed or can be placed, an inlet () to the first chamber () and an outlet () from the first chamber (), at least one second chamber () provided with or adapted to be provided with an anaerobic generation means () and/or an anaerobic detection indicator, wherein the at least one second chamber () is connected to the first chamber () by a communication path (), wherein the communication path () is liquid-tightly closed by a tap device () in a first position (A) of the tap device () and is adapted to be opened to allow fluid communication between the first chamber () and the at least one second chamber () in that the tap device () is moved to a second position (B) of the tap device ().

Sample preparation device

A membrane support, usable for example in a membrane filtration device, comprises a support surface provided on an upstream side of the membrane support and adapted to support a flat filtration membrane thereon, and a drainage structure arranged below the support surface to collect a fluid that has passed the filtration membrane supported on the support surface and guide the fluid away to a downstream side, wherein the support surface has a plurality of recesses distributed over the support surface and formed to absorb expansions of the filtration membrane. The membrane support avoids fold formation of a membrane due to membrane expansion after hydration.

Membrane support and membrane filtration device

A fluid transfer device comprising a first reservoir () having a predetermined sub-ambient pressure and volume and a presealed opening (), a second reservoir () containing a predetermined volume of a fluid (M) and having a presealed opening (), and a chamber () having an internal space () and an inlet () to the space () adapted to be connected to the opening () of the second reservoir () and an outlet () from the space () adapted to be connected to the opening () of the first reservoir ().

Fluid transfer device and process of aseptically transferring a fluid

A sample preparation device comprising a first chamber containing a first movable piston separating a first volume upstream and a second volume downstream the first piston, a second chamber containing a second movable piston separating a third volume upstream and a fourth volume downstream the second piston, and an inlet to the first volume and an outlet from the first volume. The first volume is connected with the third volume by a first communication path and the second volume is connected with the fourth volume by a second communication path.

Sample preparation device and method of preparing a sample for sterility testing

A sample preparation device, preferably for sterility testing, comprising a manifold including one or more receptacles for filtration units and at least one inlet and/or outlet port. The receptacle(s) is/are respectively provided with one or more connectors for establishing a fluid connection with mating ports of the filtration units and media containers/vials upon insertion of the same into the respective receptacles. The connectors are in fluid communication with the inlet and outlet port(s) via channels defined in the manifold to allow a desired fluid transfer through the manifold.

A take-off needle comprises a hollow lance having a distal end adapted to perform a insertion operation, said hollow lance being connected to at least one pipe provided with a spigot for it to be connected to a tube, and comprising a body for holding the hollow lance and pipe relative to each other such that the spigot projects from the holding body, said needle timber comprising two flanges held on respective sides of and spaced from the holding body by virtue of a spacer disposed between each flange and the holding body, said flanges extending in a longitudinal direction from the spigot to the vicinity of the proximal end of the hollow lance, the width of each flange being greater than the width of the portion of the holding body facing the flanges.

Holding needle comprising gripping cheeks

The device for the transfer of a medium comprises a magazine () and at least one transfer element () for transfer of said medium, said transfer element () comprising a duct () for transfer of said medium provided at one end with a needle (), a septum (), and a maneuvering unit () of said needle (), said transfer element () also comprising means for locking () adapted to cooperate with complementary locking means () of said magazine () to lock said needle () in a waiting position, said locking means () belonging to said maneuvering unit () and cooperating with said complementary locking means () at a location of said magazine () distinct from the location through which said duct () issues from the cavity (), at the opposite end from the needle ().

Device for the transfer of a medium

The assembly comprises a filtration unit and a gel growth medium cassette, the unit and the cassette being adapted to cooperate in order to occupy a nested position in which a membrane covers the gel growth medium, the unit and the cassette each being equipped with an intermediate stop, it being possible for at least one of the two stops to move clear so as to allow the unit to move from an intermediate position, in which the membrane is spaced away from the said gel growth medium, into the nested position. The method comprises selecting such an assembly, of engaging the unit on the cassette until the intermediate stop of the unit comes into contact with the intermediate stop of the cassette, and the step of moving clear the stop able to move clear so as to allow the unit to move from the intermediate position into the nested position.

Microbiological analysis assembly and method

A take-off needle comprises a hollow lance having a distal end adapted to perform a insertion operation, said hollow lance being connected to at least one pipe provided with a spigot for it to be connected to a tube, and comprising a body for holding the hollow lance and pipe relative to each other such that the spigot projects from the holding body, said needle further comprising two flanges held on respective sides of and spaced from the holding body by virtue of a spacer disposed between each flange and the holding body, said flanges extending in a longitudinal direction from the spigot to the vicinity of the proximal end of the hollow lance, the width of each flange being greater than the width of the portion of the holding body facing the flanges.

The assembly comprises a filtration unit and a gel growth medium cassette, the unit and the cassette being adapted to cooperate in order to occupy a nested position in which a membrane covers the gel growth medium, the unit and the cassette each being equipped with an intermediate stop, it being possible for at least one of the two stops to move clear so as to allow the unit to move from an intermediate position, in which the membrane is spaced away from the gel growth medium, into the nested position. The method comprises selecting such an assembly, of engaging the unit on the cassette until the intermediate stop of the unit comes into contact with the intermediate stop of the cassette, and the step of moving clear the stop able to move clear so as to allow the unit to move from the intermediate position into the nested position.

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Rosheim, France

Stephane Olivier