Sanofi-aventis

Aventis Pharma S.a.

Sanofi-a Ventis Deutschland Gmbh

Rhone-poulenc Rorer S.a.

Stephane Mutti

Luc Grondard

Joel Malpart

Maxime Lampilas

Philippe Boffelli

Michel Delthil

Lahlou Nait-Bouda

Joerg Rieke-Zapp

Michel Lavigne

Joerg Reike-Zapp

Jean-Claude Barriere

Michel Cheve

Wolfgang Holla

Frank Zocher

Berndt Kulitzscher

Bernd Junker

Patrick Lefevre

Jochen Hachtel

Thomas Stuedemann

Christoph Tappertzhofen

Christophe Salagnad

Rolf Hoerlein

Claus-Jügen Maier

Veronique Crocq-Stuerga

The invention relates to a novel method for the synthesis of N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5 -difluorophenyl)methylsulfonamide.

Method and intermediates for the preparation of derivatives of N-(1-benzhydrylazetidin-3-yl)-N-phenylmethylsulfonamide

The invention relates generally to a process for preparing diarylcycloalkyl derivatives of the formula (I). wherein the respective R-group substituents are defined herein. These compounds of formula (I) are activators for peroxisome proliferator-activated receptors (PPAR activators) which are useful in the therapeutic treatment of a number of diseases and disorders of the central nervous system such as multiple sclerosis, Parkinson's Disease, psychiatric disorders and the like. The present invention is a novel process for preparing PPAR activators of the formula (I) which do not have the disadvantages of the processes known in the prior art. In particular, a process is provided with which the PPAR activators of formula (I) can be prepared in a suitable enantiomeric excess, i.e. high enantioselectivity, without the need for subsequent chiral chromatography.

Method for the production of diarylcycloalkyl derivatives

The present invention relates to a novel method for the preparation of azetidine derivatives such as N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-quinol-6-ylmethylsulfonamide and the dihydrochloride thereof and N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulfonamide.

Product, method and intermediates for the preparation of azetidine derivatives

The invention relates to a novel method for the synthesis of N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulfonamide.

Method and intermediates for the preparation of derivatives of N (1-benzhydrylazetidin-3-yl)-N-phenylmethylsulfonamide

Novel processes for the preparation of a compound of the thiazolo[3,4,5-de] [4,1]benzothiazepine type and in particular of 2-imino-9-trifluoromethyl-4,5-dihydro-2H,7H-thiazolo[3,4,5-de] [4,1]benzothiazepine 6,6-dioxide methanesulfonate and (R,S)-2-imino-9-trifluoromethyl-4,5-dihydro-2H,7H-thiazolo[3,4,5-de] [4,1]benzothiazepine 6-oxide and its enantiomers and their pharmaceutically acceptable salts.

Process for the manufacture of a product of the thiazolo [3,4,5-de] [4,1]benzothiazepine type

Method for preparing streptogramins

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Le Perreux sur Marne, France

Stephane Mutti