Adir Et Compagnie

Les Laboratoires Servier

Stephane Leonce

Alain Pierre

Ghanem Atassi

Gilbert Lavielle

Gilbert Regnier

Alain Dhainaut

Patrick Hautefaye

Laurence Kraus-Berthier

Pierre Renard

Daniel-Henri Caignard

John Hickman

Claude Guillonneau

Emile R Bisagni

Yves Charton

Sylvain Routier

Gerard Coudert

Franck LePifre

Nathalie Ayerbe

Substituted [1,4] benzodioxino[2,3-e] isoindole derivatives, method for preparing and pharmaceutical compositions containing same

A compound of formula (I) ##STR1## in which: m, and n, which may be identical or different, represent 0 or 1,

Bisimide compounds

The compounds of formula: ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and A are as defined in the description, their optical isomers and N-oxides and addition salts thereof with a pharmaceutically acceptable acid or base, and their use as anti-tumour agents.

Ellipticine compounds

A compound of formula (I) ##STR1## in which: X and Y, which may be identical or different, represent hydrogen or halogen or alkyl, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylamino, or dialkylamino,

The compounds are trisubstituted triazines and pyrimidines useful for the suppressing the resistance of tumour cells to anti-cancer agents and for suppressing the resistance of parasites to anti-parasitic agents. A compound disclosed is 2,4-diallylamino-6-{4-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl) methylamino]piperidin-1-yl}-1,3,5-triazine.

Trisubstituted triazines

The compounds are 2,4-(optionally substituted amino)-6-substituted s.triazines, useful for suppressing the resistance of tumour cells to anti-cancer agents and for suppressing the resistance of parasites to anti-parasitic agents. A compound disclosed is 1-[4,6-bis(allylamino)-2-s-triazinyl]-4-[2,2-bis(p.fluorophenyl)ethylamino ]piperidine.

Disubstituted polymethyleneimines

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Stephane Leonce