Bio-rad Pasteur

Stephane Jean Xavier Gadelle

Jean-Francois Hubert Delagneau

Francois Yves Rieunier

François Yves Rieunier

Denis Marie Bernárd Chenebaux

Synthetic peptides of the monomer type with 13 to 33 amino acids, in linear form or in a form cyclized by means of inter-cysteine disulphide bridges, have the general formula (I):&#x394;-Z-TrpGlyCys-&#x398;-CysTyrThrSer-&#x3a9;&#x2003;&#x2003;(I)wherein &#x394; is a biotinyl radical, a biocytinyl radical, a hydrogen atom, an acetyl (CHCO&#x2014;) radical, an aliphatic chain which may contain one or two thiol, an aldehyde functional group, or an amine functional group, Z represents peptide sequence -&#x39e;-Ser-&#x39e;-, -&#x39e;-Gln-&#x39e;-, or -&#x39e;-Asn-&#x39e;-, wherein -&#x39e;represents a peptide sequence of 0 to 9 amino acids and -&#x39e;represents a peptide sequence of 0 to 5 amino acids, &#x398;is -Arg Gly Arg Leu Ile-(SEQ ID NO: 15), -Arg Gly Arg Leu Val-(SEQ ID NO: 16), -Arg Gly Lys Leu Ile-(SEQ ID NO: 17), -Arg Gly Lys Leu Val-(SEQ ID NO: 18), -Lys Gly Arg Leu Ile-(SEQ ID NO: 19), or -Lys Gly Arg Leu Val-(SEQ ID NO: 20), &#x3a9;, attached to the &#x2014;CO&#x2014; group of serine, is a hydroxyl (&#x2014;OH) radical, an amino (&#x2014;NH) radical, an alkoxy radical having 1 to 6 carbon atoms, a peptide sequence of formula Val-&#x3a3;-&#x3a8; wherein &#x3a3; represents a sequence of formula -(AA)-Trp Asn-(AA)-(AA) wherein (AA) represents an amino acid different from lysine, (AA) represents an amino acid, and (AA) is serine or a threonine residue, and &#x3a8;, attached to the &#x2014;CO&#x2014; residue of the free AAamino acid, is OH, NH, or an alkoxy radical having from 1 to 6 carbon atoms, and a peptide sequence of formula -Val-&#x3a8; wherein &#x3a8;, attached to the &#x2014;CO&#x2014; residue of valine, is OH, NH, or an alkoxy radical having from 1 to 6 carbon atoms.

Synthetic peptides useful in biological essays for detecting infections caused by group O HIV-1 viruses

Synthetic peptides of the monomer type with 13 to 33 amino acids, in linear form or in a form cyclized by means of inter-cysteine disulphide bridges, have the general formula (I):&#x394;-Z-TrpGlyCys-&#x398;-CysTyrThrSer-&#x3a9;&#x2003;&#x2003;(I)wherein &#x394; is a biotinyl radical, a biocytinyl radical, a hydrogen atom, an acetyl (CHCO&#x2014;) radical, an aliphatic chain which may contain one or two thiol, an aldehyde functional group, or an amine functional group, Z represents peptide sequence -&#x39e;-Ser-&#x39e;-, -&#x39e;-Gln-&#x39e;-, or -&#x39e;-Asn-&#x39e;-, wherein -&#x39e;represents a peptide sequence of 0 to 9 amino acids and -&#x39e;represents a peptide sequence of 0 to 5 amino acids, &#x398; is -Arg Gly Arg Leu Ile-(SEQ ID NO: 15), -Arg Gly Arg Leu Val-(SEQ ID NO: 16), -Arg Gly Lys Leu Ile- (SEQ ID NO: 17), -Arg Gly Lys Leu Val-(SEQ ID NO: 18), -Lys Gly Arg Leu Ile-(SEQ ID NO: 19), or -Lys Gly Arg Leu Val-(SEQ ID NO: 20), &#x3a9;, attached to the &#x2014;CO&#x2014; group of serine, is a hydroxyl (&#x2014;OH) radical, an amino (&#x2014;NH) radical, an alkoxy radical having 1 to 6 carbon atoms, a peptide sequence of formula Val-&#x3a3;-&#x3a8; wherein &#x3a3; represents a sequence of formula -(AA)-Trp Asn-(AA)-(AA) wherein (AA) represents an amino acid different from lysine, (AA) represents an amino acid, and (AA) is serine or a threonine residue, and &#x3a8;, attached to the &#x2014;CO&#x2014; residue of the free AAamino acid, is OH, NH, or an alkoxy radical having from 1 to 6 carbon atoms, and a peptide sequence of formula -Val-&#x3a8; wherein &#x3a8;, attached to the &#x2014;CO&#x2014; residue of valine, is OH, NH, or an alkoxy radical having from 1 to 6 carbon atoms.

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Bievres, France

Stephane Jean Xavier Gadelle