Les Laboratoires Servier

Vernalis &r&d) Ltd.

Pharmacyclics, Inc.

Les Laboratories Servier

Vernalis Limited

Stéphane Depil

Guillaume De Nanteuil

Arnaud Le Tiran

Olivier Geneste

James Brooke Murray

I-Jen Chen

James Edward Paul Davidson

John Hickman

Patrick Casara

Thierry Le Diguarher

Jean-Michel Henlin

Jérôme-Benoît Starck

Miklós Nyerges

Christopher John Graham

Sriram Balasubramanian

Ioana Kloos

Erik J Verner

Tarak D Mody

Joseph J Buggy

David J Loury

Norbert Purro

Renata Robert

Anne Jacquet-Bescond

Marylore Chenel

Sylvain Fouliard

Compounds of formula (I): wherein R, R, R, R, R, R, R, R, R, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them

Dosing regimens, methods of treatment, controlled release formulations, and combination therapies that include bendamustine, or a pharmaceutically acceptable salt thereof and an HDAC inhibitor, or a pharmaceutically acceptable salt thereof, are described.

Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof

N-hydroxy-4-{2-[3-(N,N-dimethylaminomethyl)benzofuran-2-ylcarbonylamino]ethoxy}-benzamide of formula (I): or an addition salt thereof with a pharmaceutically acceptable acid or base, alone or in association with surgery, chemotherapy or hormone therapy treatment or radiotherapy, for use in the treatment of cancer, characterized in that it is administered for 4 consecutive days, that period being followed by 3 consecutive days without any administration of compound of formula (I), with the proviso that the chemotherapy is not FOLFOX.

Administration regime for N-hydroxy-4-{2-[3-(N,N-dimethylaminomethyl)benzofuran-2- ylcarbonylamino]ethoxy}benzamide

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Issy les Moulineaux, France

Stéphane Depil