Serono Genetics Institute S.a.

Genset S.a.

Serono Genetics Institute, Inc.

Stephane Bejanin

Hiroaki Tanaka

Bernard Bihain

Jean-Baptiste Dumas Milne Edwards

Frances Yen-Potin

Jean-Yves Giordano

Severin Jobert

Blake Denison

Barbara A Chicca

John Chicca

The invention provides polynucleotides and polypeptides encoding an isolated amyloid inhibitor protein (APIP) and compositions thereof. The polypeptides of the subject invention can be used to inhibit the catabolism or sequential cleavage of amyloid beta precursor protein (APP) by sequential cleavage of APP by beta secretase and gamma secretase.

&#x3b2;-Secretase variant

The invention concerns GENSET polynucleotides and polypeptides. Such GENSET products may be used as reagents in forensic analyses, as chromosome markers, as tissue/cell/organelle-specific markers, in the production of expression vectors. In addition, they may be used in screening and diagnosis assays for abnormal GENSET expression and/or biological activity and for screening compounds that may be used in the treatment of GENSET-related disorders.

Human cDNAs and proteins and uses thereof

The present invention relates to the field of metabolic research. Metabolic disorders, such as obesity, are a public health problem that is serious and widespread. GSSP4 polypeptides have been identified that are believed to be beneficial in the treatment of metabolic disorders. These compounds should be effective for reducing cholesterol levels, body mass, body fat, and for treating metabolic-related diseases and disorders. The metabolic-related diseases or disorders include, but are not limited to, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, diabetes, glucose intolerance, insulin resistance and hypertension.

GSSP4 polynucleotides and polypeptides and uses thereof

Isolated human vCOL16A1 polypeptide and fragments thereof

Serine carboxypeptidase hx (SCPhx) and compositions thereof

The invention concerns plasmin variants. Polynucleotides the disclosed plasmin variants are provided. Additionally, methods of using the plasmin polynucleotides and polynucleotides are provided herein.

Plasmin variants and uses thereof

The invention provides polynucleotides and polypeptides encoding an isolated amyloid inhibitor protein (APIP) and compositions thereof. The polypeptides of the subject invention can be used to inhibit the catabolism or sequential cleavage of arnyloid beta precursor protein (APP) by Sequential cleavage of APP by beta secretase and gamma secretase.

Isolated amyloid inhibitor protein (APIP) and compositions thereof

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Paris, France

Stephane Bejanin