Intervet Inc.

Intervet International B.v.

Microbial Chemistry Research Foundation

Stephan Veit

Hans Peter Niedermann

Fritz Blatter

Michael Berger

Monika Brink

Timo Rager

Alfred Stutz

Ralf Warrass

Meinrad Brenner

Guixian Hu

Tobias Kappesser

Tanja Schweisel

Kerstin Fleischhauer

Heinz-Jorg Wennesheimer

Heinz-Jörg Wennesheimer

Heinz-Joerg Wennesheimer

A process to prepare a compound of Formula (I) wherein R, Rand Rare each selected independently from hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxyl, and wherein the alkyl, alkenyl, alkynyl, and alkoxyl may be optionally substituted with one or more halogen, alkyl, alkenyl, alkynyl, and alkoxyl.

Process for preparing substituted crotonic acids

This invention relates to a method for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, inter alia, may be used to make macrolides. This invention also relates to solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms.

Macrolide synthesis process and solid-state forms

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Budenheim, Germany

Stephan Veit