Bayer Aktiengesellschaft

Bayer Corporation

Stephan Schneider

Harold C Kluender

Donald J Wolanin

Brian R Dixon

Michael C VanZandt

Scott McClelland Wilhelm

Jill E Wood

William Harrison Bullock

Guenter Hans Benz

Kerry Jeanne Combs

Rainer Endermann

Mazen Es-Sayed

Klaus-Dieter Bremm

David R Brittelli

Michael Sperzel

Mary F Fitzgerald

Graham Sturton

Rolf Henning

Burkhard Fugmann

Arnel B Concepcion

Barbara Briggs

Karl G Metzger

Karl-Heinz Schlemmer

Karl-Georg Metzger

William H Bullock

Rudiger Fischer

Gabriele Br&auml;unlich

R&uuml;diger Fischer

Gabriele Br{umlaut Over (a)}unlich

Benzofuranylsulfonates

3-Urea-pyridofurans and -pyridothiophenes are prepared by reacting appropriately substituted 3-amino-pyridofurans or -pyridothiophenes with isocyanates or isothiocyanates. The 3-urea-pyridofurans and -pyridothiophenes can be used as active ingredients in medicaments, particularly in medicaments for the treatment of acute and chronic inflammatory processes.

3-Ureido-pyridofurans and -pyridothiophenes for the treatment of inflammatory processes

Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula

Substituted 5-biarylpentanoic acids and derivatives as matrix

Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T is a substituent g roup; x is 0, 1, or 2; the group D represents ##STR2## the subscript 'e' is 2 or 3; the group R.sup.14 represents a variety of possible substituent groups of the cycloalkyl ring between D and G; the subscript 'k' is 0-2; and the group G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12 ; and R.sup.13 represents any of the side chains of the 19 noncyclic occurring amino acids.

Substituted cycloalkanecarboxylic acid derivatives as matrix

Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T is a substituent group; x is 0, 1, or 2; the group D represents ##STR2## the subscript 'e' is 2 or 3; the group R.sup.14 represents a variety of possible substituent groups on the cycloalkyl ring between D and G, and the group G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12 ; and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids.

Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The presently claimed compounds have the generalized formula ##STR1## in which each T represents a substituent group; x is 0, 1, or 2; D represents ##STR2## .delta. is 0 or 1; U' represents O, S, or N, with the proviso that when U' is N, then .delta.=0, and when U' is O or S, then .delta.=1; R.sup.14 is any of a variety of substituent groups; and G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12, R.sup.11 represents H or an alkyl group, R.sup.12 represents an alkyl group, and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids; and pharmaceutically acceptable salts thereof.

Derivatives of substituted 4-biarylbutyric acid as matrix

The invention relates to new 3-substituted cephalosporins, a process for their preparation and their use as medicaments, in particular as medicaments having antibacterial activitity.

3-Substituted cephalosporins, and their use as medicaments

The invention relates to new 3-substituted cephalosporins, to a process for their preparation and to their use as medicaments, in particular as medicaments having antibacterial activity. The invention relates to compounds of the general formula (I) ##STR1## in which X, Y, R.sup.1 and R.sup.2 have the meaning indicated in the description.

3-substituted cephalosporins, and their use as medicaments

Growing community of inventors

Wuppertal, Germany

Stephan Schneider