The United States of America, As Represented by the Secretary, Department of Health and Human Services

Other

Stephan S Monroe

Larry J Anderson

Thomas G Ksiazek

Anthony Sanchez

Pierre E Rollin

William Allan Nix

Raymond Campagnoli

M Steven Oberste

Cara Carthel Burns

Paul A Rota

Suxiang Tong

Dean D Erdman

James A Comer

Mark A Pallansch

Cynthia Goldsmith

William J Bellini

Qi Chen

Shannon L Emery

Charles D Humphrey

Joseph P Icenogle

Teresa C T Peret

Sherif R Zaki

Baoming Jiang

Roger I Glass

Michael D Bowen

Byron T Cook

Jeanette Guarner

Richard F Meyer

Christopher D Paddock

Wun-Ju Shieh

Marion Koopmans

Disclosed herein is a newly isolated human coronavirus (SARS-CoV), the causative agent of severe acute respiratory syndrome (SARS). Also provided are the nucleic acid sequence of the SARS-CoV genome and the amino acid sequences of the SARS-CoV open reading frames, as well as methods of using these molecules to detect a SARS-CoV and detect infections therewith. Immune stimulatory compositions are also provided, along with methods of their use.

Coronavirus isolated from humans

The present invention provides a nucleic acid encoding human Astrovirus serotype 2, or a unique fragment thereof. The sequence, a genomic RNA of human astrovirus serotype 2 contains 6,797 nucleotides, and is organized into three open reading frames. Also provided are purified antigenic polypeptide fragments encoded by the nucleic acid encoding human Astrovirus serotype 2, or unique portions thereof. The present invention also provides a monoclonal antibody specific for human astrovirus serotype 2 and isolated nucleic acids capable of selectively hybridizing with the nucleic acid of serotype 2, including methods for detecting the presence of serotype 2 utilizing these products.

Nucleic acids encoding human astrovirus serotype 2

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Decatur, GA, United States of America

Stephan S Monroe