Hoffmann-la Roche Inc.

Stephan Rover

Andrea Cesura

Geo Adam

Jurgen Wichmann

Francedillaois Jenck

Emmanuel Pinard

Sabine Kolczewski

Guido Galley

Alexander Alanine

Vincent Mutel

Rene Wyler

Marie-Paule Heitz Neidhart

Bernd Buttelmann

Gunther Fischer

Gerhard Trube

Anne Bourson

Frank Dautzenberg

Caido Galley

Frederick Monsma, Jr

The present invention relates to compounds of the formula ##STR1## wherein X is --O-- or --CH.sub.2 --;

Piperidine derivatives

The invention relates to compounds of the general formula ##STR1## wherein R.sup.1 is C.sub.6-12 -cycloalkyl, optionally substituted by lower alkyl or C(O)O lower alkyl, indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; acenaphthen-1-yl; bicyclo[3.3.1]non-9-yl, octahydro-inden-2-yl; 2,3-dihydro-1H-phenalen-1-yl; 2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl, decahydro-azulen-2-yl; bicyclo[6.2.0]dec-9-yl; decahydro-naphthalen-1-yl, decahydro-naphthalen-2-yl; tetrahydro-naphthalen-1-yl, tetrahydro-naphthalen-2-yl or 2-oxo-1,2-diphenyl-ethyl;

Diaza-spiro[3,5] nonane derivatives

The present invention relates to compounds of the general formula wherein

Spiro[piperidine-4,1'-pyrrolo [3,4-C] pyrrole]derivatives

The present invention relates to compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are each independently hydrogen, lower alkyl, lower alkoxy or halogen;

1,3,8-triazaspiro[4,5]decan-4-one derivatives

The present invention relates to the use of tetrahydroisoquinoline derivatives of the general formula: ##STR1## wherein: A is aryl

Octahydro phenanthridine derivatives useful as NMDA-R receptor subtype

The present invention relates to compounds of formula I and pharmaceutically acceptable acid addition salts thereof.

1,3,8,-triaza spiro (4,5)decan-4-on derivatives

The invention is concerned with the use of sulfonamide derivatives of the general formula ##STR1## wherein R Signifies lower-alkyl, phenyl, benzyl, naphthyl, pyridyl or thienyl, optionally substituted by one or more lower-alkyl, lower-alkoxy, lower-alkyl carbonyl-amino, halogen, cycloalkyl, nitro, amino, methylenedioxy, phenoxy or benzyloxy substituents, and the aromatic rings, can, in turn, be substituted by nitro, halogen or amino,

Use of N-(4-aryl-thiazol-2-yl)-sulfonamides

The present invention relates to the use of tetrahydroisoquinoline derivatives of the general formula ##STR1## wherein A is aryl

Tetrahydroisoquinoline derivatives

The invention is concerned with the use of sulfonamide derivatives of the general formula ##STR1## wherein R signifies lower-alkyl, phenyl, benzyl, naphthyl, pyridyl or thienyl, optionally substituted by one or more lower-alkyl, lower-alkoxy, lower-alkyl carbonyl-amino, halogen, cycloalkyl, nitro, amino, methylenedioxy, phenoxy or benzyloxy substituents, and the aromatic rings, can, in turn, be substituted by nitro, halogen or amino,

The novel pyrrolopyrazines of the general formula ##STR1## wherein one of R.sup.1 and R.sup.2 signifies aryl and the other signifies hydrogen, lower alkyl or aryl or R.sup.1 and R.sup.2 together with the two carbon atoms denoted by .alpha. and .beta. signify the group A; ##STR2## R.sup.3 signifies hydrogen or lower alkyl and R.sup.4 signifies hydrogen or

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Inzlingen, Germany

Stephan Rover