Dade Behring Marburg Gmbh

Behring Diagnostics Gmbh

Other

Hoechst Aktiengesellschaft

Stephan Neuenhofer

Reinhard Kasmarker

Peter Molz

Norbert Madry

Heinz-Jurgen Skrzipczyk

Eugen Uhlmann

Gerd Schnorr

Guido Simons

Hans-Peter Harthus

Henning Hachmann

Gunther Nau

Thomas Leutsch

Heinz-Juergen Skrzipczyk

Reinhard Käsmarker

Heinz-Jürgen Skrzipczyk

Reinhard K&auml;smarker

Gotz Walter

Kurt E Weimer

The invention relates to a method for the detection of an analyte in a competitive immunoassay in the presence of an analyte derivative and first and second receptor molecules, and to a kit for carrying out this detection method.

Competitive immunoassay using complexed analyte derivatives

The present invention relates to a method of carrying out an immunoassay in a multiphase system. A sample containing an analyte is brought into contact with a receptor A and a tracer. The analyte can either form a complex with the tracer, or counteract the formation of a complex of receptor A and tracer by competing with the tracer for binding to receptor A, or counteract the formation of a complex of receptor A and tracer by competing with receptor A. Receptor B is added and the signal is determined. In this method, receptor A and receptor B are suitably immobilized, ensuring that the tracer either cannot enter into any binding involving the simultaneous participation of receptors A and B or can enter into such a binding to only such a slight extent that it is nevertheless possible to detect and differentiate differing analyte concentrations.

Method for carrying out an immunoassay in a multiphase system

Method for stabilizing hydrolysis-sensitive molecules or molecular

A homogeneous gene probe test, which is based on altering the signal of the nonhybridized gene probe by a receptor directed against the label on the gene probe is described.

Homogeneous gene probe test using a receptor directed against the label

There are disclosed hapten tracer complexes which, on the one hand, contain a hapten which is linked to an indicator component and, on the other hand, an antibody which can bind specifically to the indicator component. These hapten tracer complexes can be employed advantageously in immunoassays.

Immunoassays for haptens and hapten tracer-antibody complex which can be

The invention relates to a process for the stabilization of biologically active substances which are immobilized on a carrier, where the solid phase with the immobilized biologically active substance is contacted for the stabilization with a solution which contains polyanetholesulfonic acid and/or salts thereof. The biologically active substances are, in particular, antibodies.

Process for the stabilization of biologically active substances

Growing community of inventors

Marburg, Germany

Stephan Neuenhofer