Brainlab Ag

University of California

Stephan Mittermeyer

Rowena Thomson

Kathryn H Rosenbluth

Andreas Hartlep

Christoph Pedain

Bálint Varkuti

Krystof Bankiewicz

Rainer Lachner

Maria Inmaculada Rodriguez-Ponce

Joseph Doyle

Martin Rube

Christian Harrer

Jan Felix Eschermann

The invention relates a method and an apparatus of predicting or planning a temperature distribution () in a body. The method comprises the steps of: a) obtaining a model of the body () related to a temperature transport mechanism or temperature distribution () in the body; b) simulating an application of heat to at least a part of the body such as targeted tissue; c) determining and/or predicting the temperature () or heat distribution in at least a part of the body using the model of the body ().

Method and apparatus for estimating temperature in a body

The invention relates to a computer-implemented medical data processing method for determining a heartbeat signal describing the heartbeat of a patient in the time domain, the method comprising executing, on a processor of a computer, steps of: a) acquiring, at the processor, acceleration measurement data describing an acceleration in the time domain of an anatomical body part measured on an external surface of the anatomical body part; b) determining, by the processor, component analysis data describing a result of an independent component analysis in the time domain of the acceleration measurement data; c) acquiring, at the processor, heartbeat template data describing template shapes of heartbeat in the time domain; d) determining, by the processor and based on the component analysis data and the heartbeat template data, recurrent shape data describing a recurrence of certain signal shapes in the component analysis data; e) determining, based on the recurrent shape data, heartbeat signal data describing a time series of the heartbeat.

Detection of the heartbeat in cranial accelerometer data using independent component analysis

The present invention relates to a data processing method of determining a trajectory of a medical instrument to be inserted into a patient's body for treatment of a target region in the patient's body, the method being executed by a computer and comprising the following steps:

Method for inverse trajectory planning

An agent delivery catheter including a first hollow tube and a second hollow tube that protrudes from a distal opening of the first hollow tube and defines an agent delivery lumen extending along the entire length of the catheter. The distal end of the first tube is coupled to the second tube to form an annular cavity between the first tube and the second tube, the annular cavity provided for accommodating a retractable stylet shaft. An adapting member is disposed on and coupled to a proximal end of a ceramic member and for receiving a distal end of the stylet shaft.

Agent delivery catheter

A method for planning an infusion of a medical substance into a target region acquires non-patient-specific anatomical data from an atlas in the form of target region geometry information describing target and off-target regions for which an infusion of the medical substance is intended and regions to be avoided, respectively. Target coverage information is derived describing a minimum dose of the medical substance to be infused into the target region and describing a maximum dose of the medical substance to be applied to the off-target region. Relationship information describes a relationship between a physical parameter of an infusion setup and a selected spatial distribution of the medical substance. Infusion setup information for the infusion is determined that describes a planned infusion setup and is based on the relationship information and information related to the target and off-target regions.

Method for determining an infusion parameter

The present invention relates to a data processing method for providing variation data which describe a physically-varying anatomical structure, in particular an indiscernible anatomical structure, in particular a non-enhancing tumor, comprising the steps of: providing second image data which describe a second image of a region of an anatomical body, wherein the region includes a second anatomical part which includes the physically-varying anatomical structure; providing first image data which represent a first image of the same region, wherein said same region includes a first anatomical part which does not include the physically-varying anatomical structure or which includes the physically-varying anatomical structure in a different physical state than in the second anatomical part; providing position change data which describe positional changes of corresponding image elements between the first image and the second image, on the basis of the first and second image data; and providing the variation data on the basis of the position change data.

Determination of a physically-varying anatomical structure

The present invention relates to a data processing method for determining an infusion location in an anatomical region of interest of a patient's body for infusing a medical substance, the method being executed by a computer and comprising steps of: a) acquiring permeability data comprising information about the permeability of anatomical vessels in the body; b) acquiring body vessels set data comprising information about a body vessel set, wherein the body vessel set represents a set of at least one anatomical body vessel in the patient's body and wherein the body vessel set data comprises information about the spatial structure of the at least one body vessel; c) acquiring coverage condition data comprising information about a predetermined coverage of a target region with the medical substance; d) determining, for a plurality of candidate infusion locations, candidate coverage data comprising information about a candidate coverage of a target region with the medical substance based on the permeability data, the body vessel set data and the coverage condition data; e) determining infusion location data comprising information about the infusion location based on the permeability data, the body vessel set data and the coverage condition data.

Method for optimising local drug delivery

A method for planning an infusion of a medical liquid by an infusion apparatus comprising an infusion device, wherein the method comprises the steps of: acquiring planning scan data which represent a medical image of at least a body region () of a patient and are obtained by a planning scan before the infusion device is positioned; determining a planned device position from the planning scan data; acquiring verification scan data which represent a medical image of the region of the patient after the infusion device has been positioned; determining a source volume of the liquid from the verification scan data; and determining infusion parameters from the verification scan data and the source volume.

Computer-assisted infusion planning and simulation

The invention relates to a catheter stylet for stiffening a catheter during the placing process, wherein the stylet comprises an accommodating lumen for at least one fluid-guiding line of the catheter. It also relates to a catheter stylet catheter system, comprising such a stylet and comprising a catheter which comprises a fluid-guiding line, and to a method for stiffening a catheter during the placing process, wherein a stylet which comprises an accommodating lumen is arranged around at least one fluid-guiding line of the catheter.

Catheter stylet with catheter accommodating lumen

A drug supply system for CED (convection-enhanced delivery) catheter infusions is provided, the system including a drug conducting system having a drug depot and a catheter supply line and a conveying device that provides for conveying the drug from the drug depot into the catheter supply line. The drug conducting system is a system that is closed to the outside in a fluidic seal The drug supply system further includes a conveying fluid conveying system arranged between the conveying device and the drug supply system and is connected to the conveying device and to the drug depot, via a drug displacement element, without fluid-drug contact.

Drug supply system for CED (convection-enhanced delivery) catheter infusions

A catheter for administering a substance into body tissues includes an elongated catheter body that has at least one portion of the length of the catheter body that expands after the catheter is inserted in the patient's body. The portion that expands provides a seal against backflow of the substance along the outer surface of the catheter body and away from the intended treatment area.

Growing community of inventors

Landshut, Germany

Stephan Mittermeyer