The United States of America, As Represented by the Secretary, Department of Health and Human Services

Universitätsklinikum Freiburg

Stephan Mielke

William Douglas Figg

Alex Sparreboom

Tristan M Sissung

Klaus Mross

Dirk Behringer

The present disclosure provides methods of identifying subjects having an increased likelihood of developing one or more adverse side effects resulting from administration of a microtubule-stabilizing agent. In particular examples, the method includes determining whether the subject has an ABCB1 predictive polymorphism for microtubule-stabilizing agent-induced toxicity, wherein the presence of such a polymorphism indicates that the subject has an increased risk of developing microtubule-stabilizing agent induced adverse effects. Examples of ABCB1 predictive polymorphisms include 2677G&#x3e;T/A and 3435C&#x3e;T. Also provided are methods of modifying microtubule-stabilizing agent therapy in a subject identified as having one or more ABCB1 predictive polymorphisms. Kits and isolated nucleic acid molecules that can be used in the disclosed methods are also provided.

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Loehne, Germany

Stephan Mielke