Pentracor Gmbh

Stephan Mattecka

Ahmed Sheriff

Birgit Vogt

Roderich Süssmuth

Victor Prisyazhnoy

Roderich Sussmuth

The present invention provides phosphoryl choline derivatives of general formula (I), which are suitable to be immobilized on a solid support to provide a separation material of general formula (II), which bind with both high affinity and high specificity to a protein, more specifically to C-reactive protein and anti-phosphoryl choline antibodies. Said separation materials are particularly useful in the extracorporeal removal of C-reactive protein and anti-phosphoryl choline antibodies from a biological fluid of a patient for prophylaxis and/or treatment of immune dysfunctions and cardiovascular diseases. Also provided is a column that comprises the separation material of general formula (II), as well as a device containing the column. Formula (I), wherein variable X is selected from: &#x2014;SH, &#x2014;NHR, &#x2014;C&#x2550;CH, &#x2014;CH&#x2550;CH, &#x2014;Nand &#x2014;CHO; the other variables are as defined in the claims: Formula (II), wherein variable 'A' represents a solid support. 'A' as well as the other variables are defined in detail in the claims. 

Separation material comprising phosphoryl choline derivatives

The invention relates to the use of a citrate solution for affinity-chromatographic removal of C-reactive protein (CRP) from biological fluids, wherein the CRP is affinity-chromatographically removed using (Ca-dependent) binding of CRP to a column material functionalized with &#x3c9;-phosphonooxyalkyl ammonium groups and/or with &#x3c9;-ammoniumalkoxy-hydroxy-phosphoryloxy groups.

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Berlin, Germany

Stephan Mattecka