Neste Oyj

Neste Oil Oyj

Stephan Hetzler

Perttu Koskinen

Alexander Steinbuchel

Alexander Steinbüchel

Daniel Broker

Daniel Bröker

Shanna Sichwart

Stefan Uthoff

Birgit Haschenhermes

This invention relates to cells and methods for producing lipids using cellulosic carbon source. More specifically the invention relates to oleaginous bacterial cells, wherein genes encoding at least one cellulolytic activity has been introduced. This invention also relates to methods for lipid production by cultivating an oleaginous bacterial strain or strains capable of expressing one or more cellulolytic activity.

Oleaginous bacterial cells and methods for producing lipids

Disclosed are microorganisms of the genusor, which are genetically modified to express phosphomannose isomerase (EC5.3.1.8) and facilitated diffusion protein (EC1.3.1.74) for mannose uptake, and optionally mannofructokinase (EC2.7.1.4). The microorganisms also may be genetically modified to express xylose isomerase (EC 5.3.1.5), xylulokinase (E 2.7.1.17) and xylose proton symporter E or a high affinity ABC-transporter. The genetically modified microorganisms are capable of growing on mannose, xylose, arabinose, glucose, or galactose, or a combination thereof as the carbon source.

Microorganisms with extended substrate utilization range

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Munster, Germany

Stephan Hetzler