Hoechst Aktiengesellschaft

Aventis Pharma Deutschland, Gmbh

Stephan Henke

Dietrich Brocks

Martin Bickel

Volkmar Gunzler

Hartmut Hanauske-Abel

Jochen Knolle

Gerhard Breipohl

Harald Burghard

Klaus Wirth

Georg Tschank

Ekkehard Baader

Jurgen Mohr

Bernward Scholkens

Hermann J Gerhards

Gunther Jung

Leander Lauffer

Karl-Heinz Wiesmuller

Birgit Jordan

Susanne Feiertag

Volker Teetz

Wolfgang Konig

Holger Heitsch

Hans-Wolfram Fehlhaber

Irvin Winkler

Max Hropot

Wolfgang Schmidt

Hiristo Anagnostopulos

Franz Hock

Volkmar Gunzler-Pukall

Kari I Kivirikko

Horst Kunz

Gabriele Wiemer

Hans-Georg Alpermann

Jens Stechl

Karin Molling

Till Opatz

Volkmar Gunzlen-Pukall

Raili M Myllyla

Volkmar Gunzier

Volkmar G Unzler

Fred Lembeck

Tobias Wunberg

Christopher Kallus

Substituted tetrahydropyrane derivatives, method for producing same, their use as medicine or diagnostic agent, as well as medicine containing same

Ring fused dihydropyrans, process for preparation and use thereof

The invention relates to the use of bradykinin antagonists for the production of pharmaceuticals for the treatment and prevention of Alzheimer's disease. Suitable bradykinin antagonists are peptides which inhibit the effects of the Alzheimer's protein amyloid (&bgr;/A4) on isolated endothelial cells. A particularly suitable peptide is H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH (HOE 140) and its physiologically tolerable salts.

Use of peptidic bradykinin antagonists for the treatment and prevention of Alzheimer's disease

The invention relates to compounds of the formula I

Cyclohexapeptides and their mixtures, a process for preparing them, and

This invention relates to a method of treating a chronic fibrogenetic liver disorder and/or an acute liver disorder and/or complications associated therewith, comprising administering to a patient a therapeutically effective amount of a bradykinin antagonist. Particular complications associated with said liver disorders include portal hypertension, decompensation phenomena such as ascites, edema formation, hepatorenal syndrome, hypertensive gastropathy and colopathy, splenomegaly and hemorrhagic complications in the gastrointestinal tract due to portal hypertension, collateral circulation and hyperemia and a cardiopathy as a result of a chronically hyperdynamic circulatory situation and its consequences.

Use of bradykinin antagonists for the production of pharmaceuticals for

Bradykinin antagonists and their physiologically tolerated salts are suitable for the treatment or prophylaxis of virus diseases.

Bradykinin antagonists for the prophylaxis or treatment of virus diseases

The invention relates to pyridine-2,4- and -2,5-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and X have the meanings given, a process for the preparation of these compounds and their use, in particular in medicaments for influencing the metabolism of collagen and collagen-like substances or the biosynthesis of Cl.sub.q.

Pharmaceutical use of pyridine-2,4- and -2,5-dicarboxylic acid amides

Peptides having bradykinin antagonist action

The invention relates to compounds of the formula ##STR1## in which A denotes an optionally substituted radical from the series comprising alkyl, acyl, cycloalkyl, aryl and heteroaryl; A.sup.1 represents CO, CS, C.dbd.NH, CN-alkyl, CN--O-alkyl, SO, optionally substituted CH.sub.2 or a bond; A.sup.2 represents NH, NCH.sub.3, O, CH.sub.2 or a bond; E represents CHOH, CO, SO or optionally N-substituted C.dbd.NH; A.sup.3 represents O, NH, NCH.sub.3 or a bond; R.sup.4 denotes an optionally substituted radical from the series comprising alkyl, cycloalkyl, aryl and heteroaryl; and R.sup.8 denotes hydrogen or optionally substituted alkyl, to a process for their preparation, and to their use as inhibitors of prolyl hydroxylase.

2,3-disubstituted isoxazolidines, a process for their preparation,

Bradykinin peptides with modifications at the N terminus

The invention relates to pyridine-2,4- and -2,5-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2, 3.sup.3, R.sup.4 and X have the meanings given, a process for the preparation of these compounds and their use, in particular in medicaments for influencing the metabolism of collagen and collagen-like substances or the biosynthesis of Cl.sub.q.

Medicaments based on pyridine-2,4- and 2,5-dicarboxylic acid amides

The invention relates to compounds of the formula ##STR1## in which A denotes an optionally substituted radical from the series comprising alkyl, acyl, cycloalkyl, aryl and heteroaryl; A.sub.1 represents CO, CS, C=NH, CN-alkyl, CN-O-alkyl, SO, optionally substituted CH.sub.2 or a bond; A.sub.2 represents NH, NCH.sub.3, O, CH.sub.2 or a bond; E represents CHOH, CO, SO or optionally N-substituted C=NH; A.sub.3 represents O, NH, NCH.sub.3 or a bond; R.sup.4 denotes an optionally substituted radical from the series comprising alkyl, cycloalkyl, aryl and heteroaryl; and R.sup.8 denotes hydrogen or optionally substituted alkyl, to a process for their preparation, and to their use as inhibitors of prolyl hydroxylase.

2,3-disubstituted isoxazolidines, agents containing them and their use

The invention relates to pyridine-2,4- and -2,5-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2 and X have the meanings given, a process for the preparation of these compounds and their use, in particular in medicaments for influencing the metabolism of collagen and collagen-like substances or the biosynthesis of C1.sub.q.

Pyridine-2,4- and dicarboxylic acid derivatives, the use thereof and

The invention relates to substituted pyridine-2,4-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1 and R.sup.2 have the meanings given. The invention also relates to a process for the preparation of the abovementioned compounds and to their use as medicaments, in particular as fibrosuppressants and immunosuppressants.

Substituted pyridine-2,4-dicarboxylic acid compounds and the use thereof

Growing community of inventors

Bad Soden am Taunus, Germany

Stephan Henke