Degussa Aktiengesellschaft

Evonik Degussa Gmbh

Other

Stephan Hans

Brigitte Bathe

Walter Pfefferle

Georg Thierbach

Lothar Eggeling

Mechthild Rieping

Natalie Schischka

Wilfried Claes

Alexander Reth

Miroslav Patek

Mike Farwick

Thomas Hermann

Caroline Kreutzer

Bettina Mockel

Hermann Sahm

Bettina Moeckel

Caroline Reynen

Caroline Kruetzer

Sahm Hermann

Bettina Möckel

Gerd Seibold

Alexander Henrich

Reinhard Krämer

The invention relates to a microorganism which produces and/or secretes an organic-chemical compound, wherein the microorganism has increased expression, compared to the particular starting strain, of one or more protein subunits of the ABC transporter having the activity of a trehalose importer, said microorganism being capable of taking up trehalose from the medium; and to a method for the production of an organic-chemical compound, using the microorganism according to the invention, wherein accumulation of trehalose in the fermentation broth is reduced or avoided.

Microorganism and method for the fermentative production of an organic-chemical compound

The invention relates to an isolated polynucleotide having promoter activity, a variant of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase; and to a microorganism which produces and/or secretes a fine chemical, the microorganism including the isolated polynucleotide having promoter activity, which enables various genes to be overexpressed in comparison with the particular starting strain; and to a process for preparing fine chemicals using the microorganism.

Variants of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase

The invention relates to processes for fermentative production of L-proline using bacteria which contain mutated variants of the proB gene.

Mutant of the proB gene from coryneform bacteria

L-lysine-producing strains ofwith enhanced lysE gene (lysine export carrier gene), in which strains additional genes chosen from the group comprising the dapA gene (dihydrodipicolinate synthase gene), the lysC gene (aspartate kinase gene), the dapB gene (dihydrodipicolinate reductase gene) and the pyc gene, but especially the dapA gene and the lysC gene (aspartate kinase gene), are enhanced and, in particular, over-expressed, and a process for the preparation of L-lysine.

L-lysine-producing corynebacteria and process for the preparation of L-lysine

The invention relates to mutated variants of the proB gene from coryneform bacteria, which encode &#x3b3;-glutamyl kinase, and to processes for fermentative production of L-proline using bacteria which contain this mutation.

Variant polynucleotide for increasing L-proline production

The invention relates to mutants and alleles of the coryneform bacterium mqo gene which encodes malate quinone oxidoreductases which contain any amino acid apart from L-serine at position 111, or a comparable position, in the amino acid sequence, and to processes for fermentatively preparing amino acids, preferably L-lysine, L-tryptophan and L-proline, using bacteria which comprise these alleles.

Alginate gel scaffold having a plurality of continuous parallel microtubular copper capillaries

The invention relates to alleles of the sigA gene from coryneform bacteria which code for sigma factors A and a process for the fermentative preparation of L-lysine using bacteria which contain these alleles.

Alleles of the sigA gene from coryneform bacteria

The invention relates to L-lysine-producing strains of corynebacteria with enhanced lysE gene (lysine export carrier gene), in which strains additional genes chosen from the group comprising the dapA gene (dihydrodipicolinate synthase gene), the lysC gene (aspartate kinase gene), the dapB gene (dihydrodipicolinate reductase gene) and the pyc gene, but especially the dapA gene and the lysC gene (aspartate kinase gene), are enhanced and, in particular, over-expressed, and to a process for the preparation of L-lysine.

The invention relates to alleles of the glk gene from coryneform bacteria coding for glucokinases, and to processes for the production of L-lysine by fermentation using bacteria containing such alleles.

Coryneform bacteria with altered glucokinase activity in the production of L-lysine

Alleles of the mqo gene from coryneform bacteria

The present invention provides nucleotide sequences from Coryneform bacteria which code for the PtsI protein and a process for the fermentative preparation of amino acids using bacteria in which the ptsI gene is enhanced.

Nucleotide sequences coding for the PtsI protein

An isolated polynucleotide which contains a polynucleotide sequence selected from the group comprising:

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Osnabrueck, Germany

Stephan Hans