Salix Pharmaceuticals, Inc.

Global Blood Therapeutics, Inc.

Vitae Pharmaceuticals, Inc.

Reata Pharmaceuticals, Inc.

Amgen Inc.

Astrazeneca Ab

Vertex Pharmaceuticals, Inc.

Nektar Therapeutics

Ambit Biosciences Corporation

Exelixis, Inc.

Chdi Foundation, Inc.

Photocure Asa

Telik, Inc.

Mutual Pharmaceutical Company, Inc.

Takeda Pharmaceuticals U.s.a., Inc.

Stephan D Parent

Travis Lee Houston

David T Jonaitis

Patricia Andres

Melanie Janelle Bevill

Wei Lai

Yiduo Wu

Zhe Li

David Thomas Jonaitis

Jason A Hanko

Lisa Lynn McQueen

Hugh Young Rienhoff, Jr

Amy E Tapper

Jared Peters Smit

John M Brackett

Paul Schields

Huamin Zhang

Jih Hua Liu

Fei Ding

David A Claremon

Suresh B Singh

Linghang Zhuang

Lawrence Wayne Dillard

Jing Yuan

Robert J Zamboni

Yajun Zheng

Salvacion Cacatian

Lanqi Jia

Yi Fan

Shankar Venkatraman

Stephen D Lotesta

Chengguo Dong

Andrew Marcus

Paul Robert Mcguirk

Angel Morales-Ramos

Robert M Kral, Jr

Tong Sun

John Allen Walling

Courtney S Johnson

Jinyu Shen

Shripad S Bhagwat

Alan N Schwartz

Martin Hans Bohlin

Fang Wang

Petinka I Vlahova

John R Snoonian

Carl-Johan Aurell

Philip L Nyce

Alex Eberlin

Valeriya N Smolenskaya

Nathan Carl Schultheiss

Todd Blythe

Tesfai Sebhatu

Michael Hurrey

Travis Houston

Eric Thomas Healy

David Richard Jensen

Celia Dominguez

Mark E Gurney

Steven R Schow

Khalid Ali Shah

Robert T Lum

Leticia M Toledo-Sherman

Ron C Kelly

Peter H Wong

David Alan Engers

Henry Morrison

Mary Chaves

Roman Shimanovich

Jason S Tedrow

Darren Leonard Reid

Prashant Agarwal

Yonglai Yang

Jordan Michael Croom

Shawn Watson

Jian-Xie Chen

Jon Philip Lawson

Nate Schultheiss

Bengt Leonard Åslund

Bo Ingvar Ymén

Melanie J Roe

Jon Erik Brænden

Richard James Ely

Chunsheng Qiao

Dennis A Bennett

Vinod Khetarpal

Frenel DeMorin

Pamela A Smith

Sagar Shakya

Charles H Montgomery

Stephen R Byrn

Ami Sanat Bhavsar

Larry Robin Chan

Adrian Radocea

Geetha Banda

Dale K Purcell

Melanie Bevill

Courtney Johnson

Bruce Charles Friedman

Bengt Aslund

Forms of (S)-2-hydroxy-6-((4-(2-(2-hydroxyethyl)nicotinoyl)morpholin-3-yl)methoxy)benzaldehyde (Compound I), or salts or solvates thereof, were prepared and characterized in the solid state. Also provided are processes of manufacture and methods of using the forms of Compound I.

Solid forms of a modulator of hemoglobin

Crystalline salts of psilocin are disclosed. The beneficial and therapeutic uses of the crystalline psilocin salts and of compositions containing the crystalline psilocin salts are also disclosed. The disclosure sets out methods of making and characterizing the crystalline psilocin salts.

Crystalline salts of psilocin

Disclosed herein are salt and solvate forms of. (1S,3'R,6′R,7′S,8′E,11′S,12′R)-6-chloro-7′-methoxy-11′,12′-dimethyl-3,4-dihydro-2H,15′H-spiro[naphthalene-1,22′-[20]oxa[13]thia[1,14]diazatetracyclo[14.7.2.00]pentacosa[8,16,18,24]tetraen]-15′-one 13′,13′-dioxide (AMG 176): such as crystalline salt and solvate forms thereof. Also disclosed are methods of making the salt and solvate forms, and methods of treating diseases and disorders with the salt and solvate forms.

Salt forms and solvates of Mcl-1 antagonists

The present disclosure is related to a polymorphic form of ritonavir prepared by novel methods that require less time to produce the polymorphic form, the methods of preparing the polymorphic form, pharmaceutical compositions comprising the polymorphic form produced by the provided methods, and corresponding methods of treatment with the polymorphic form produced by the provided methods.

Processes for preparing solid state forms

The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Inhibitors of the menin-MLL interaction

The present invention provides a crystalline form and stable salts of 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(2-propanyl)-3-pyridinyl)-4-((2S)-2-methyl-4-(2-propenoyl)-1-piperazinyl)pyrido[2,3-d]pyrimidin-2(1H)-one, including several hydrochloride salt forms, phosphate salt form, mesylate salt form, and solid state forms thereof, pharmaceutical compositions, and methods of treating a disease mediated by KRAS G12C inhibition.

Solid state forms

Provided are crystals of 2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate, compositions comprising the same, and methods of making and using such crystals.

Crystals

The present invention relates to crystalline forms of the free base of the c-Met inhibitor, Compound 1. The invention also relates to crystalline forms of salts of Compound 1. The invention also relates to pharmaceutical compositions comprising the solid polymorphs of the free base and salts of Compound 1. The invention further relates to methods of treating a disease, disorder, or syndrome mediated at least in part by modulating in vivo activity of a protein kinase.

Crystalline forms and salt forms of a kinase inhibitor

Disclosed are crystalline free base ansolvate forms of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde (or Compound 1), such as the free base Form I, Form II and Material N. Also disclosed are crystalline free base solvates of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde (or Compound 1).

Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde

Forms of 6-(3-chloro-4-cyclopropoxyphenyl)pyrimidine-4-carboxylic acid (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the forms of Compound I and salts or co-crystals thereof.

Solid forms of a kynurenine-3-monooxygenase inhibitor

Provided herein are free base crystalline forms and crystalline salts of Compound 1.

Salts and polymorphs of a PDE4 inhibitor

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West Lafayette, IN, United States of America

Stephan D Parent