University of Miami

Stephan C Schürer

Anthony J Capobianco

Xiaoxia Zhu

Tanya T Kelley

Disclosed herein are Notch transcriptional activation complex kinase (“MACK”) inhibitors, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein include compounds of Formula (Ia) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

Inhibitors of the Notch transcriptional activation complex kinase ('NACK') and methods for use of the same

Disclosed herein are Notch transcriptional activation complex kinase ('NACK') inhibitors, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein include compounds of Formula (la) and pharmaceutically acceptable salts thereof: wherein the substituents are as described. 

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Coral Gables, FL, United States of America

Stephan C Schürer