R.p.scherer Technologies, Inc.

Stepan Chuprakov

David Rabuka

Romas Alvydas Kudirka

Jesse M McFarland

Ayodele O Ogunkoya

Albert W Garafalo

Penelope M Drake

Junjie Liu

The present disclosure provides antibody-drug conjugate (ADC) structures, which include a camptothecine or a camptothecine derivative linked to a polypeptide (e.g., an antibody) through a linker. The disclosure also encompasses compounds and methods for production of such conjugates, as well as methods of using the conjugates.

Camptothecine antibody-drug conjugates and methods of use thereof

The present disclosure provides antibody-drug conjugate structures, which include a cleavable linker that links the antibody to the drug and has a first enzymatically cleavable moiety and a second enzymatically cleavable moiety which includes a glycoside selected from a galactoside, a glucoside, a mannoside, a fucoside, O-GlcNAc, and O-GalNAc. The disclosure also encompasses compounds and methods for production of such conjugates, as well as methods of using the conjugates.

Glycoside dual-cleavage linkers for antibody-drug conjugates

The present disclosure provides antibody-drug conjugate structures, that include a cleavable linker having a sulfatase-cleavable moiety. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.

Sulfatase-cleavable linkers for antibody-drug conjugates

The present disclosure provides conjugate structures and hydrazinyl-substituted heteroaryl compounds used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates and compounds, as well as methods of using the same.

Growing community of inventors

Emeryville, CA, United States of America

Stepan Chuprakov