University of California

Amydis, Inc.

Spinogenix, Inc.

Amydis Diagnostics, Inc.

Stella Sarraf

Emmanuel A Theodorakis

Jerry Yang

Gerald F Swiss

Vincent F Simmon

Suhail Rasool

Elizabeth Büchler Vadas

Lyndsay M Randolph

Provided herein are crystalline forms of 2-(2-(2-(2-(4-(benzo[d]thiazol-2-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethan-1-ol (Compound I): Also provided are processes of manufacture and methods of using the crystalline forms.

Solid forms of a promoter of spinogenesis

The present disclosure relates generally to compositions and methods for determining whether a patient suffers from a traumatic brain injury (TBI) by detecting the presence of an amyloid beta protein in an eye of the patient. Also provided are compositions and methods for preparing a patient for diagnosis and treatment of traumatic brain injury (TB).

Compositions and methods for detection of traumatic brain injury

Disclosed are compounds that promote spinogenesis, are capable of reducing the neural toxicity of beta-amyloid peptides, and/or reduce the symptoms of traumatic brain injury in a patient.

Benzothiazole and related compounds

Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.

Amyloid targeting agents and methods of using the same

Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are the methods for treating of diseases associated with an amyloid or amyloid like proteins.

Growing community of inventors

Beverly Hills, CA, United States of America

Stella Sarraf