Amersham Biosciences Ab

Amersham Pharmacia Biotech Ab

Clavis Pharma Asa

Clavis Pharma As

Steinar Hagen

Finn Myhren

Marit Liland Sandvold

Ole Henrik Eriksen

Geir Fonnum

Jan Roger Karlson

Torunn Arntsen

Rune Ringberg

The present invention relates to certain unsaturated fatty acid derivatives of therapeutically active glucocorticoides-fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents and pharmaceutical formulations containing them.

Fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents

This invention relates to certain unsaturated fatty acid derivatives of therapeutically active 1,3-dioxolane nucleoside analogues and to pharmaceutical formulations containing them. The said derivatives fall within formula (I). Compounds of formula (I) can be used in the treatment of a cancerous disease, including solid tumors and haematological cancers such as leukaemias, lymphomas and multiple myelomas. 

Dioxolane derivates for the treatment of cancer

A method of manufacturing a support media from a cross-linked polymerisate based on vinyl compounds, and exhibiting residual vinyl groups. The characteristic feature of the method is that the polymerisate is subjected to a heating step that preferably is carried out under reduced access of oxygen. The use of the support media is also described.

Manufacturing method and article produced by the method

A polymer article having structure (I), where P comprises the basic polymer and groups &mdash;L&mdash;CH(&mdash;X(R ) )&mdash;CH (&mdash;Y(R ) ); L is a part of a pending group utilized for introducing &mdash;X(R ) and &mdash;Y(R ) ; X and Y are halogen, N, S and O; R is hydrogen, alkyl, acyl or R when X is N, O or S; R is hydrogen, alkyl, alkylaryl or arylalkyl in which the alkyl part may contain carbons, or &mdash;R (&mdash;NH&mdash;CR &boxH;O) or &mdash;R (&mdash;NH ) , &mdash;CR &boxH;O or poly alkyloxy that may have been terminally acylated or alkylated; p is an integer with the provisos a) p depends on X being halogen, O, S or N, and b) that if several groups R are present they may be identical or different; R is alkyl, &mdash;O-alkyl, hydroxyalkyl, phenylalkyl, with up to carbon atoms in the alkyl part, and R is C alkyl. q is an integer>O representing that one or more hydrogens in R may have been replaced with &mdash;NH or &mdash;NH&mdash;CR &boxH;O. The polymer article may be used as a chromatography separation medium or in solide phase oligonucleotide synthesis.

Coated polymer article and its use

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Hagan, Norway

Steinar Hagen