Koninklijke Philips Corporation N.V.

Lumileds Holding B.v.

Koninklijke Philips Electronics N.v.

Philips Intellectual Property & Standards Gmbh

Stein Kuiper

Bernardus Hendrikus Wilhelmus Hendriks

Bernardus H W Hendriks

Jan Frederik Suijver

Christina Adriana Renders

Bokke Johannes Feenstra

Sjoerd Stallinga

Christopher Stephen Hall

Grigoriy Basin

Teunis Willem Tukker

Robert Andrew Hayes

Rudolph M Snoeren

Paul Scott Martin

Johannes Wilhelmus Weekamp

Johannus Wilhelmus Weekamp

Coen Theodorus Hubertus Fransiscus Liedenbaum

Nijs Cornelis Van Der Vaart

Anna Teresa Fernandez

Johannes Petrus Maria Ansems

Arjen Gerben Van Der Sijde

Mark Jozef Willem Mertens

Christoph Gerard August Hoelen

Szabolcs Deladi

Johannes Joseph Hubertina Barbara Schleipen

Albert Hendrik Jan Immink

Waltherus Cornelis Jozef Bierhoff

Willem Gerard Ophey

Jeff Shimizu

Michel Marcel Jose Decre

Marinus Bastiaan Van Leeuwen

Nenad Mihajlovic

Ivon Franciscus Helwegen

Chien Ting Chin

Marco A J Van As

Bas Hulsken

Edwin Maria Wolterink

Bas Jan Emile Van Rens

Derk Visser

Gerhard Spekowius

Yan Shi

Anton Petrus Maria Van Arendonk

Antonius Johannes Josephus Rademakers

Andrei Mijiritskii

Marco Andreas Jacobus Van As

Derk J W Klunder

Gerjan Franciscus Arthur Van De Walle

Albert H J Immink

Waltherus C J Bierhoff

Zeynep Seflek Unay

Gert T Hooft

Erik Robbert Vossenaar

Cornelius Antonius Micolaas Maria Van Der Vleuten

Bo Joakim Isaksson

Gerardus J J Vos

Thomas Pierre Cornil Duriez

Jozef Elisabeth Aubert

Robert W J Zijlstra

Bart E G J Van Meerbergen

Coen Theodorus Hubertus Fran Liedenbaum

Ronald Tabaksblat

Gerardus Johannes Josephus Vos

Bas J E Van Rens

Mark W G Ponjee

Willem G Ophey

Antonius J J Rademakers

Johannus W Weekamp

Cornelius A N M Van Der Vleuten

Erik Robert Vossenaar

Anton P M Van Arendonk

Bart E G Van Meerbergen

Marc W G Ponjee

Zeynep S Unay

A lens system comprises a first lens group and a second lens group, and is configured to form an image at a first magnification and at a second magnification. The lens system has a common optical axis in both magnifications. The lens system is further configured to form an intermediate image between the first lens group and the second lens group at the first magnification. The intermediate image formed in the first magnification is further imaged onto an optical detector. In the first magnification, the second lens group acts as a relay lens imaging the intermediate image onto the optical detector. In the second magnification, the first and second lens groups together form an image on the optical detector without forming an intermediate image.

Lens system

An objective lens system for an optical biopsy device has a lens that comprises a first part configured for viewing at a first magnification, and a second part configured for viewing at a second magnification. The second magnification is substantially different from the first magnification. The first magnification enables viewing a larger area of a target and the second magnification enables viewing the target at a cellular level with high sensitivity and specificity. Combining viewing at two different magnifications in a single objective lens results in a compact optical biopsy device.

Optical biopsy device

A method for fabricating an LED/phosphor structure is described where an array of blue light emitting diode (LED) dies are mounted on a submount wafer. A phosphor powder is mixed with an organic polymer binder, such as an acrylate or nitrocellulose. The liquid or paste mixture is then deposited over the LED dies or other substrate as a substantially uniform layer. The organic binder is then removed by being burned away in air, or being subject to an Oplasma process, or dissolved, leaving a porous layer of phosphor grains sintered together. The porous phosphor layer is impregnated with a sol-gel (e.g., a sol-gel of TEOS or MTMS) or liquid glass (e.g., sodium silicate or potassium silicate), also known as water glass, which saturates the porous structure. The structure is then heated to cure the inorganic glass binder, leaving a robust glass binder that resists yellowing, among other desirable properties.

Phosphor in inorganic binder for LED applications

The invention provides a lighting unit comprising a light source and a light conversion layer, wherein the light source is configured to provide light source light and comprises a light emitting diode (LED), wherein the light conversion layer comprises an alkali silicate matrix containing a particulate luminescent material, and wherein the light conversion layer is configured to convert at least part of the light source light into luminescent material light.

Phosphor in water glass for LEDS

A method of analyzing a sample fluid containing organic microobjects is proposed. The method comprises the steps of: up-concentrating (S) the microobjects by removing, in a total time T, a volume Vof the sample fluid from the upconcentrate sample microobjects; immersing (S) the microobjects in a transfer fluid, or leaving the microobjects in a remaining portion of the sample fluid, the remaining portion of the sample fluid then providing the transfer fluid; filtering (S), in a total time T, a volume Vof the transfer fluid by a filter, thereby accumulating the microobjects on the filter; and generating (S) an image of the microobjects accumulated on the filter; wherein the throughput V/Tof the step of up-concentrating (S) is greater than the throughput V/T, of the step of filtering (S). The filter may be a second filter, and the step of up-concentrating (S) may involve: filtering the sample fluid by a first filter, thereby accumulating the microobjects on the first filter. An apparatus or system for analyzing a sample fluid containing organic microobjects is also disclosed.

Up-concentration of organic microobjects for microscopic imaging

The invention relates to a method of determining in vitro the amount of nuclear DNA within a human or animal cell using UV absorption measurement with UV light. The invention also relates to a method for detecting in vitro cancerous cells in a biological sample relying on the aforementioned principles. The invention also relates to an in vitro method of diagnosing or predicting the likely occurrence of cancer in a human or animal subject.

Vitro method of detecting and/or diagnosing cancer using UV light based DNA image cytometry

At least two chemically different substances of interest of an unstained biological specimen that for each a substance image is generated, indicating for every region of the image an amount of the substance. A multicolor image is generated on the basis of the substance images.

Generation of a multicolour image of an unstained biological specimen

The invention relates to an electrowetting-on-dielectric device (). This is an electro wetting device comprising one or more cells, wherein each cell comprises an electrowetting composition of first and second immiscible fluids, the first fluid being an electrolytic solution (), a first electrode (), separated from the electrowetting composition by a dielectric (), and a voltage source () for applying an operating voltage difference between the first electrode () and the electrolytic solution to operate the electrowetting device. According to the invention, the first electrode () of the electrowetting-on-dielectric device () comprises a valve metal, and the electrolytic solution () is capable of anodizing the valve metal to form a metal oxide at the operating voltage difference. This provides the electrowetting-on-dielectric device () with self-repairing properties thereby preventing breakdown of the dielectric. As a result, the electrowetting device can be operated at a low voltage, and it has an improved reliability.

Electrowetting device

An acoustic probe () includes an acoustic transducer (), and a plurality of variably-refracting acoustic lens elements () coupled to the acoustic transducer. Each variably-refracting acoustic lens element has at least a pair of electrodes () adapted to adjust at least one characteristic of the variably-refracting acoustic lens element in response to a selected voltage applied across the electrodes. In one embodiment, each variably-refracting acoustic lens element includes a cavity, first and second fluid media () disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.

Methods and apparatuses of microbeamforming with adjustable fluid lenses

A catheter apparatus includes an elongated body having proximal and distal ends, and an acoustic transducer disposed proximate the distal end of the elongated body. A variably-refracting acoustic lens is provided to dynamically adjust a direction associated with an acoustic wave coupled to the acoustic transducer in response to one or more control signals provided thereto.

Catheter for three-dimensional intracardiac echocardiography and system including the same

The disclosure is directed to a system for variably refracting, and is transparent for, ultrasound as well as for light. By choosing liquids with the right optical and acoustical properties, it is possible to variably refract (including focusing and deflecting or steering) ultrasound while not affecting the refraction of light, or vice versa. Two lenses in series, or preferably one lens, allow for variably refracting ultrasound and light.

System for variably refracting ultrasound and/or light

An imaging system with two modalities has a catheter with an optical lens system situated at an end of the catheter and optically connected to optical guide. The lens system has a numerical aperture which is changeable between a first aperture and a second larger numerical aperture. The imaging system also has an imaging unit for optical imaging with the catheter. First and second imaging modalities are optically connectable with the optical lens system of the catheter. The imaging system can change between imaging in two modes: (1) the first numerical aperture of the optical lens system and the first imaging modality of the imaging unit, and (2) the second numerical aperture of the optical lens system and the second imaging modality of the imaging unit.

Imaging system with two imaging modalities

An adjustable fluid type lens system is provided that allows e.g. ultrasound imaging through the lens during adjustment of the lens. The lens includes a container enclosing two immiscible fluids, e.g. water and oil, being in contact with each other at an interface. Incoming waves are then refracted at this interface. The shape of the interface, and thereby the refraction property, is adjustable by adjusting a voltage applied to the lens. The two fluids are selected such that they together exhibit a mechanical damping which is critical or near critical. A control circuit generates the electric voltage for adjusting the refraction from one value to another, the control circuit being arranged to change the electric voltage such that a rate of voltage change is limited to avoid oscillation of the interface, thereby adjusting refraction of incoming waves at the interface in a continuous manner. This makes it possible to use the lens while it is during adjustment from one refraction value to another, since the interface shape will at all time during the adjustment have a controlled shape. The voltage can be either a continuous voltage or a discrete stepwise (digital) voltage which is just controlled with respect to step size and temporal extension of the steps. The lens system has a number of applications e.g. within the medical field, e.g. for 'on the fly' high speed ultrasound imaging, or for ultrasound ablation applications where ablation can be performed during adjustment of the lens to follow a pre-defined trajectory.

Adjustable lens system for real-time applications

The present invention relates to an autostereoscopic display device, comprising an imaging layer () and a lens layer (). The lens layer () serves to project different content from the imaging layer () to the left and right eyes, respectively, of a user. The lens layer () comprises lens cells (), enclosing two fluids () with different refractive indices. The shape of the interface between the fluids may be changed using electrowetting, by means of two individually controllable electrodes () at the sides of each lens cell (). The display device further comprises a user head tracking device and means for controlling the lens cell electrodes depending on a detected user head position. This allows the display device to display a correct 3D-image, even if the user moves his head.

Autostereoscopic display device

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Eindhoven, Netherlands

Stein Kuiper